Hepatic glucose sensing is required to preserve β cell glucose competence
Graph Chatbot
Chattez avec Graph Search
Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.
AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.
Insulin resistance, tissue inflammation, and adipose tissue dysfunction are features of obesity and Type 2 diabetes. We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice to investigate the function of NCoR in adipocyte bi ...
For patients with type 1 diabetes mellitus, appropriate control of blood glucose concentrations is vital. Exercise is one of the disturbances that can affect these concentrations. Therefore, predictions in the presence of exercise are useful among others f ...
For type 1 Diabetes, insulin injection therapy is the most used treatment today, and insulin pumps are surely the most accurate therapeutic strategy. The insulin use temperature has to not exceed 37°C to prevent unwanted degradation and loss of function. T ...
Type 1 Patients with Diabetes (Type 1 PwDs) have to frequently adjust their insulin dosage to keep their Blood Glucose concentration (BG) within normal bounds. Meal intakes represent the most important disturbance that has to be accounted for. Its effect d ...
Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI) candidiasis is common. We recently demonstrated that the PPAR gamma ...
Objective - Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin sensitive tissues is associat ...
Diabetes mellitus is a globally growing disease with more than 180 million cases worldwide and no cure exists. In order to minimize the many medical complications, tight glucose monitoring has been shown to be the best alternative. Many diabetics require i ...
Hypoglycemia is common during development and is associated with the risk of neurodevelopmental deficits in human infants. The effects of hypoglycemia on the developing hippocampus are poorly understood. The sequential changes in energy substrates, amino a ...
The multifactorial mechanisms promoting weight loss and improved metabolism following Roux-en-Y gastric bypass (GB) surgery remain incompletely understood. Recent rodent studies suggest that bile acids can mediate energy homeostasis by activating the G-pro ...
The physiological contribution of glucose in thermoregulation is not completely established nor whether this control may involve a regulation of the melanocortin pathway. Here, we assessed thermoregulation and leptin sensitivity of hypothalamic arcuate neu ...