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Hemodynamic forces affect endothelial cell morphology and function. In particular, circumferential cyclic stretch of blood vessels, due to pressure changes during the cardiac cycle, is known to affect the endothelial cell shape, mediating the alignment of ...
An ever more complete picture of the organization and function of the endocytic pathway is emerging. New mechanisms, and in particular lipid- based mechanisms that couple membrane dynamics and sorting, are being unraveled. But the final picture is still co ...
We report the sequence, structure and distribution of a novel transient receptor potential (trp) homologue from Xenopus, Xtrp, determined by screening an oocyte cDNA library. On the basis of sequence similarity and predicted structure, Xtrp appears to be a ...
We present mol. dynamics simulations of bovine rhodopsin in a membrane mimetic environment based on the recently refined x-ray structure of the pigment. The interactions between the protonated Schiff base and the protein moiety are explored both with the c ...
The alpha-toxin from Staphylococcus aureus undergoes several conformational changes from the time it is released from the bacterium to the moment it forms a channel in the plasma membrane of its target cell. It is initially a soluble monomer, which undergo ...
Fatty acid amide hydrolase (FAAH) is an integral membrane protein responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. Analysis of FAAH's primary sequence re ...
The attachment of a tetradecyl chain to the ionophore 18-crown-6 leads to a stronger interaction with a supported lipid monolayer. Some C14-18-crown-6 mols. introduced in the aq. phase are incorporated in the phospholipid membrane. This process is used to ...
A review with 130 refs. on optical techniques such as total internal reflection fluorescence, waveguides, and SPR for the detection of mol. interactions of membrane receptors. The outlook on how these emerging techniques may be applied to solve important q ...
Conformational changes occurring upon membrane binding and subsequent insertion of staphylococcal alpha-toxin were studied using complementary spectroscopic techniques. Experimental conditions were established where binding could be uncoupled from membrane ...
Many central biol. signal transduction processes such as synaptic transmission occur at the level of cell membranes. It is therefore not surprising that the biol. function of membrane proteins in general and neuroreceptors in particular can be modulated by ...
