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Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls

Publications associées (69)

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Host determinants of HIV-1 control in African Americans

Jacques Fellay

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associa ...

2010

Association Study of 182 Candidate Genes in Anorexia Nervosa

Pierre Magistretti

We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results in the literature (182 candidate ge ...

2010

Host genetics and HIV-1: the final phase?

Jacques Fellay, Amalio Telenti

This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral ...

2010

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

Nouchine Hadjikhani, Fei Chen

Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution(1). Recent extensive genome-wide association studies (GWASs) have identified numerous si ...

2010

Common genetic variation and the control of HIV-1 in humans

Jacques Fellay, Patrick Descombes, Amalio Telenti

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the ...

2009

X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women

Jacques Fellay

AIDS has changed from a mostly male-specific health problem to one that predominantly affects females. Although sex differences in HIV-1 susceptibility are beyond doubt, the extent to which sex affects the onset and progression of AIDS has remained elusive ...

2009

Host genetics influences on HIV type-1 disease

Jacques Fellay

HIV host genetic studies seek to describe as comprehensively as possible the effect of human genetic variation on the individual response to HIV type-1 (HIV-1) infection. Many associations between specific gene variants and HIV-1 disease outcomes have been ...

International Medical Press2009

A whole-genome association study of major determinants for host control of HIV-1

Jacques Fellay, Patrick Descombes, Amalio Telenti

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly ...

2007

Circuits and Systems for High-Throughput Biology

Giovanni De Micheli, Luca Benini

The beginning of this millennium has been marked by some remarkable scientific events, notably the completion of the first objective of the Human Genome Project [HGP], i.e., the decoding of the 3 billion bases that compose the human genome. This success ha ...

2006