Publication
Lactate brain metabolism in different mouse strains probed by hyperpolarized 13C MRS
Publications associées (34)
Parkinson mice show functional and molecular changes in the gut long before motoric disease onset
Background: There is increasing evidence that Parkinson's disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons in the midbrain ...
BMC2021Supervised learning to quantify amyloidosis in whole brains of an Alzheimer's disease mouse model acquired with optical projection tomography
Dimitri Nestor Alice Van De Ville, Theo Lasser, Aleksandra Radenovic, Paul James Marchand, Arielle Louise Planchette, Virginie Sophie Uhlmann, David Nguyen
Alzheimer's disease (AD) is characterized by amyloidosis of brain tissues. This phenomenon is studied with genetically-modified mouse models. We propose a method to quantify amyloidosis in whole 5xFAD mouse brains, a model of AD. We use optical projection ...
2019Monitoring the energy of the metal ion-content plasma-assisted deposition and its implication for bacterial inactivation
Cu-polyester (Cu-PES) was sputtered by high power impulse magnetron sputtering (HIPIMS) and by low energy direct current magnetron sputtering (DCMS). The total amount and distribution of the Ar+, Cu+ and Cu2+ ions were determined as well as the bacterial i ...
ELSEVIER SCIENCE BV2019The virtuous cycle of human genetics and mouse models in drug discovery
Ongoing studies in many species seek to understand the origins, architecture and consequences of phenotypic variation under normal and dysfunctional conditions, with the aim of identifying targets for intervention that can prevent, stabilize or reverse dis ...
NATURE PUBLISHING GROUP2019Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo
Bernard Lanz, Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Sylvain Eric Lengacher, Yuhei Takado
The dynamics of L-lactate transport across the blood-brain barrier (BBB) and its cerebral metabolism are still subject to debate. We studied lactate uptake and intracellular metabolism in the mouse brain using hyperpolarized C-13 magnetic resonance spectro ...
2018Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population
Johan Auwerx, Jun Yong Kim, Dongryeol Ryu, Evan Graehl Williams, Pooja Jha, Jiayi Lan, Ruedi Aebersold, Moaraj Hasan
We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from genetically diverse BXD mouse strains in two fractions (mitochondria and total cell) from five tissues: liver, quadriceps, heart, brain, and brown adipose (BA ...
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2018Evidence for differentiated ionic and surface contact effects driving bacterial inactivation by way of genetically modified bacteria
New evidence is presented for the bacterial inactivation of E. coli presenting normal porins on sputtered Ag-Cu surfaces compared with similar E. coli porinless bacteria. Inactivation at a reduced rate was observed on the genetically modified porinless bac ...
Royal Society of Chemistry2017Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Theo Lasser, Tristan Bolmont, Taoufiq Harach, Nicolas Jean Marc Antoine Duthilleul
Alzheimer’s disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number o ...
2017Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla
Rolf Gruetter, Lijing Xin, Hongxia Lei, Bernard Lanz
(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...
Nature Publishing Group2015Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform
Genome-wide manipulations and measurements have made huge progress over the last decades. In Saccharomyces cerevisiae, a well-studied eukaryotic model organism, homologous recombination allows for systematic deletion or alteration of a majority of its gene ...
EPFL2015