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Background: Synaptic interactions between excitatory and inhibitory neocortical neurons are important for mammalian sensory perception. Synaptic transmission between identified neurons within neocortical microcircuits has mainly been studied in brain slice ...
The possibility of changing the number of synapses may be an important asset in the treatment of neurological diseases. In this context, the synaptogenic role of the phosphoinositide-3-kinase (PI3K) signaling cascade has been previously demonstrated in Dro ...
Magnetic resonance spectroscopy (MRS) allows measurement of neurotransmitter concentrations within a region of interest in the brain. Inter-individual variation in MRS-measured GABA levels have been related to variation in task performance in a number of r ...
In the brainstem auditory circuit of mammals and birds, excitatory synapses with extraordinarily large size have evolved, which ensure fast membrane potential signaling mediated by large, multiquantal excitatory postsynaptic currents (EPSCs). The so-called ...
For neural network simulations on parallel machines, Interprocessor spike communication can be a significant portion of the total simulation time. The performance of several spike exchange methods using a Blue Gene/P (BG/P) supercomputer has been tested wi ...
We study the role of network architecture in the formation of synchronous clusters in synaptically coupled networks of bursting neurons. We give a simple combinatorial algorithm that finds the largest synchronous clusters from the network topology. We demo ...
How learning and memory is achieved in the brain is a central question in neuroscience. Key to today’s research into information storage in the brain is the concept of synaptic plasticity, a notion that has been heavily influenced by Hebb’s (1949) postulat ...
Neurons in the brain form complicated networks through synaptic connections. Traditionally, functional connectivity between neurons has been analyzed using simple metrics such as correlation, which do not provide direction of influence. Recently, an inform ...
In this contribution we present multi-channel microinjector arrays fabricated by a reliable three-layer SU-8 process for the local delivery of specific substances into brain tissue. They are designed to be assembled with previously developed. implantable b ...
The distribution of synaptic efficacies in neocortex has an approximately lognormal shape. Many weak synaptic connections coexist with few very strong connections such that only 20% of synapses contribute 50% of total synaptic strength. Furthermore, recent ...
