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The potential of HDAC inhibitors as cognitive enhancers
Publications associées (52)
Syntheses and biological activity of the HDAC class I inhibitor largazole
A review. Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the potential to combat cancer on an epigenetic level. The recently reported marine natural product largazole was recently isolated in trace amts. from cya ...
Swiss Chemical Society2009The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes
One of the central questions in eukaryotic transcription is how activators can transmit their signal to stimulate gene expression in the context of chromatin. The multisubunit SAGA coactivator complex has both histone acetyltransferase and deubiquitination ...
2008Insulin secretion: SIRT4 gets in on the act
Despite their initial characterization as histone deacetylases controlling transcription, sirtuins also turn out to be critical regulators of metabolism. In this issue of Cell, Haigis et al. (2006) demonstrate that the mammalian Sir2 homolog SIRT4 acts in ...
2006Unconventional Catalytic Mechanism for histone deacetylase suggested by a DFT-QM/MM study
Histone deacetylases (HDACs) constitute an important family of zinc-dependent enzymes responsible for catalyzing the cleavage of acetyl groups from acetyl-lysine residues in histone N-terminal tails. HDACs can potentially play a key role treating various c ...
2006Unexpected Deacetylation Mechanism Suggested by a Density Functional Theory QM/MM Study of Histone-Deacetylase-Like Protein
To characterize the catalytic mechanism for zinc-dependent histone deacetylases (HDAC), we have carried out d. functional theory (DFT) QM/MM studies on the deacetylation reaction catalyzed by a histone-deacetylase-like protein (HDLP). The calcn. results do ...
2006