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Competing islands limit the rate of adaptation in structured populations
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Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...
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The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that i ...
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Mechanochromic luminescent materials, exhibiting a change in luminescence behavior under external stimuli have emerged as one of the promising candidates for upcoming efficient OLEDs. Recently mechanochromic luminescence was reported in a donor-acceptor-do ...
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The fixation probability of a single mutant invading a population of residents is among the most widely-studied quantities in evolutionary dynamics. Amplifiers of natural selection are population structures that increase the fixation probability of advanta ...
PUBLIC LIBRARY SCIENCE2020On the relation between transversal and longitudinal scaling in cities
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Does the scaling relationship between population sizes of cities with urban metrics like economic output and infrastructure (transversal scaling) mirror the evolution of individual cities in time (longitudinal scaling)? The answer to this question has impo ...
2020Direct coupling analysis of epistasis in allosteric materials
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In allosteric proteins, the binding of a ligand modifies function at a distant active site. Such allosteric pathways can be used as target for drug design, generating considerable interest in inferring them from sequence alignment data. Currently, differen ...
2020Cellular memory enhances bacterial chemotactic navigation in rugged environments
The response of microbes to external signals is mediated by biochemical networks with intrinsic time scales. These time scales give rise to a memory that impacts cellular behaviour. Here we study theoretically the role of cellular memory in Escherichia col ...
NATURE PUBLISHING GROUP2020