Publication
Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity
Publications associées (34)
Kinetic reconstruction and analysis of sphingolipid metabolism
Vassily Hatzimanikatis, Howard Riezman, Georgios Savoglidis
Lipids are major constituents of the cell, implicated with its functional and structural properties, along with a number of chronic diseases. Applying computational techniques with systematic modeling of lipids can provide insights about mechanisms that re ...
2014Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis
Fabrice David, Howard Riezman, Manuele Piccolis
The regulatory pathways required to maintain eukaryotic lipid homeostasis are largely unknown. We developed a systematic approach to uncover new players in the regulation of lipid homeostasis. Through an unbiased mass spectrometry-based lipidomic screening ...
Amer Soc Cell Biology2014A computational framework for integration of lipidomics data into metabolic pathways
Vassily Hatzimanikatis, Noushin Hadadi, Keng Cher Soh, Marianne Seijo, Aikaterini Zisaki
Lipids are important compounds for human physiology and as renewable resources for fuels and chemicals. In lipid research, there is a big gap between the currently available pathway-level representations of lipids and lipid structure databases in which the ...
Academic Press Inc Elsevier Science2014Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy
Rolf Gruetter, João Miguel das Neves Duarte, Kim Do
Alterations to brain homeostasis during development are reflected in the neurochemical profile determined noninvasively by (1)H magnetic resonance spectroscopy. We determined longitudinal biochemical modifications in the cortex, hippocampus, and striatum o ...
Elsevier Science Inc2014Biochemical Membrane Lipidomics during Drosophila Development
Françoise Gisou van der Goot Grunberg, Xue Li Guan, Ernst Hafen
Lipids play critical roles in energy homeostasis, membrane structure, and signaling. Using liquid chromatography and mass spectrometry, we provide a comprehensive semiquantification of lipids during the life cycle of Drosophila melanogaster (230 glyceropho ...
Elsevier2013Integrating omics data into metabolic models of lipids: a platform for the identification of gene mutations from lipidomics data
Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis
Kinetic models of metabolic networks are mapping the biochemical reactions taking part in a cell to a mathematical representation. They are the blueprints of the biochemical network, connecting enzymatic activities and metabolic compounds. Kinetic models h ...
2013Kinetic modeling of the yeast sphingolipid metabolism identifies prevalent mutant strains through integration of lipidomic data profiles
Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis
Sphingolipids are abundant components of eukaryotic cells. Their localization in the plasma membrane allows for the cell to carry out multiple important functions for its viability. One of the most important roles of the sphingolipids is their ability to f ...
2012The journey of resveratrol from yeast to human
The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie ...
2012The journey of resveratrol from yeast to human
The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie ...
2012The metabolic footprint of aging in mice
Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Raphaël Doenlen, Richardus Houtkooper, Ellen Helena Jeninga
Aging is characterized by a general decline in cellular function, which ultimately will affect whole body homeostasis. Although DNA damage and oxidative stress all contribute to aging, metabolic dysfunction is a common hallmark of aging at least in inverte ...
2011