A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans
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Mitochondria are essential organelles participating in numerous cellular functions, including energy harvesting, regulation of homeostasis and apoptosis. Changes in mitochondrial number, morphology, and function not only impact cellular metabolism but also ...
Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological relevance as gatekee ...
Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed more than 1,300 barcoded P. berghei mutants through the life cycle. We dis ...
Coupled dynamical systems are omnipresent in everyday life. In general, interactions between
individual elements composing the system are captured by complex networks. The latter
greatly impact the way coupled systems are functioning and evolving in time. ...
In complex network-coupled dynamical systems, two questions of central importance are how to identify the most vulnerable components and how to devise a network making the overall system more robust to external perturbations. To address these two questions ...
Identifying key players in coupled individual systems is a fundamental problem in network theory. We investigate synchronizable network-coupled dynamical systems such as high-voltage electric power grids and coupled oscillators on complex networks. We defi ...
American Association for the Advancement of Science (AAAS)2019
Supplementation with the NAD(+) precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously show ...
2019
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Complex network theory describes network performance mostly based on topological characteristics, like betweenness centrality. This work integrates concepts from complex networks and traffic engineering. We propose a new measure for spatial networks and, i ...
2020
The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...
Background & Aims: Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases. Methods: We performed high-throughput sequencing of ...
