Riding the whole-genome data tsunami: a landscape genomic study of local adaptation in Moroccan sheep and goats
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The evolutionary history of the human pygmy phenotype (small body size), a characteristic of African and Southeast Asian rainforest hunter-gatherers, is largely unknown. Here we use a genome-wide admixture mapping analysis to identify 16 genomic regions th ...
The recent availability of whole genome sequence (WGS) data implies to reconsider sampling strategies in landscape genomics for economic reasons. Indeed, while we had many individuals and few genetic markers ten years ago, we now face the contrary with hig ...
In 2008, FAO and WAAP published a report on production environment descriptors for animal genetic resources. One of the main conclusions was that it was necessary to quickly systematize the recording of breeds’ geographical coordinates worldwide in order t ...
Sheep (Ovis aries) have been well adapted to thrive in a diverse range of climates during the domestication and breed development process. These climate-mediated selective pressures have shown to influence phenotypic variation within and among breeds and, ...
Motivation: Comparative genomics aims to understand the structure and function of genomes by translating knowledge gained about some genomes to the object of study. Early approaches used pairwise comparisons, but today researchers are attempting to leverag ...
Summary Understanding the peopling of the Americas remains an important and challenging question. Here, we present 14C dates, and morphological, isotopic and genomic sequence data from two human skulls from the state of Minas Gerais, Brazil, part of one of ...
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that th ...
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have b ...
Motivation: The increasing availability of high-throughput datasets requires powerful methods to support the detection of signatures of selection in landscape genomics. Results: We present an integrated approach to study signatures of local adaptation, pro ...
Comparative genomics aims to understand the structure of genomes and the function of various genomic fragments, by transferring knowledge gained from well studied genomes, to the new object of study. Rapid and inexpensive high-throughput sequencing is maki ...
