Publication
Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade
Publications associées (33)
Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth
Michele De Palma, Nadine Fournier, Stefanie Siegert, Mauro Delorenzi, Mario Leonardo Squadrito, Sina Nassiri, Pascale Anderle Pedone, Simone Ragusa, François Renevey
Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...
London2022The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing
Matthias Lütolf, Jeffrey Alan Hubbell, Yoji Tabata, Jun Ishihara, Kazuto Fukunaga
During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...
AMER SOC HEMATOLOGY2019Periostin Limits Tumor Response to VEGFA Inhibition
Michele De Palma, Ioanna Keklikoglou, Ece Kadioglu, Axel Bellotti
Resistance to antiangiogenic drugs limits their applicability in cancer therapy. Here, we show that revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are depen ...
Elsevier B.V.2018Microenvironmental regulation of tumour angiogenesis
Michele De Palma, Daniela Biziato
Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cel ...
Nature Publishing Group2017Design principles for therapeutic angiogenic materials
Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez
Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis - the proc ...
Nature Publishing Group2016Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)
Veronica Sacchi, Jeffrey Alan Hubbell, Mikaël Martino, Kristen Lorentz, Martin Ehrbar, Elena Groppa
Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene delivery failed to show efficacy. Major challenges include the need to precisely control in vivo distribution of growth factor dose and duration of expression. Re ...
Natl Acad Sciences2014Vascular Modulatory Functions of Macrophages
Michele De Palma, Ioanna Keklikoglou
Monocytes/macrophages have long been regarded as important regulators of angiogenesis and vascular remodeling in both developmental and pathological processes. Historically, the ability of macrophages to promote vascular growth has been primarily attribute ...
Springer2014Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1
The endothelium plays a pivotal role in the progression of solid tumors and is considered a highly relevant target for therapy. However, it emerges that current clinical angiogenesis inhibitors that act through inhibition of tumor-derived growth factors ar ...
2013The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)
Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino
Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...
Elsevier2013Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches
Michele De Palma, Mario Leonardo Squadrito
The ability of macrophages to promote vascular growth has been associated with the secretion and local delivery of classic proangiogenic factors (e.g., VEGF-A and proteases). More recently, a series of studies have also revealed that physical contact of ma ...
Elsevier Inc2013