Publications associées à An Efficient Drug Metabolism Strategy Based on Microsome-Mesoporous Organosilica Nanoreactors

First-Principles Study of Non-heme Fe(II) Halogenase SyrB2 Reactivity

We present here a computational study of reactions at a model complex of the SyrB2 enzyme active site. SyrB2, which chlorinates L-threonine in the syringomycin biosynthetic pathway, belongs to a recently discovered class of alpha-ketoglutarate (alpha KG), ...

2009

Three-Phase Catalytic Hydrogenation of a Functionalized Alkyne: Mass Transfer and Kinetic Studies with in Situ Hydrogen Monitoring

Albert Renken, Lioubov Kiwi, Martin Grasemann

Systematic studies of mass transfer interactions with intrinsic reaction kinetics were performed for the threephase selective hydrogenation of 2-methyl-3-butyn-2-ol (MBY) to 2-methyl-3-buten-2-ol (MBE) over a modified Pd/CaC

{O}_{3}

catalyst under solvent ...

2008

Pd Nanoparticles in a Supported Ionic Liquid Phase: Highly Stable Catalysts for Selective Acetylene Hydrogenation under Continuous-Flow Conditions

Paul Joseph Dyson, Lioubov Kiwi, Gabor Laurenczy, Marina Ruta

Monodispersed Pd nanoparticles of 5 and 10 nm were obtained via reduction of Pd(acac)2 dissolved in ionic liquid (IL), [bmim][PF6], or [bmimOH][TF2N], supported on carbon nanofibers (CNF) anchored to sintered metal fibers (SMF). Using [bmimOH][TF2N], the m ...

2008

Fast temperature cycling of the catalytic CO oxidation using microstructure reactors

Martin Luther

The possibility to increase the performance (productivity or selectivity) of a chemical reactor by using periodic variations of reaction parameters (e.g. reactant concentration or temperature) has been theoretically envisaged since the beginning of the 70t ...

EPFL2008

Forced periodic temperature cycling of chemical reactions in microstructure devices

Albert Renken, Lioubov Kiwi, Martin Luther

In this publication, several stainless steel microstructure reactors specially designed to obtain rapid and periodic temperature changes are presented. Different microstructure reactor designs have been manufactured and tested for their thermal behaviour a ...

2008

Synthesis of monodispersed palladium nanoparticles to study structure sensitivity of solvent-free selective hydrogenation of 2-methyl-3-butyn-2-ol

Albert Renken, Lioubov Kiwi, Danièle Laub

A novel method for isolation of monodispersed Pd nanoparticles from a reverse microemulsion was developed using hydrocarbon evaporation and methanol-assisted particle purification from a surfactant. Fcc Pd nanoparticles of 6, 8, 11, and 13 nm in diameter w ...

2007

Proton shuttles and phosphatase activity in soluble epoxide hydrolase

Matteo Dal Peraro

Recently, a novel metal Mg2+-dependent phosphatase activity has been discovered in the N-terminal domain of the soluble epoxide hydrolase (sEH), opening a new branch of fatty acid metabolism and providing an additional site for drug targeting. Importantly, ...

2007

Determination of adjusted neutron spectra in different MUSE configurations by unfolding techniques

Rakesh Chawla, Michaël Plaschy

Investigations of spectrum adjustment by unfolding techniques for different locations of critical and driven subcritical MUSE4 configurations are presented. The current analysis is based on the recent accomplishment of specific foil activation measurements ...

American Society for Testing and Materials2006

Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease

The neuropathological and clinical symptoms of Huntington's disease (HD) can be simulated in animal model with systemic administration of 3-nitropropionic acid (3-NP). Energy defects in HD could be ameliorated by administration of coenzyme Q10 (CoQ10), cre ...

2006

Hydrogénation sélective du 2-butyne-1,4-diol avec des catalyseurs de palladium supportés sur des matériaux filamenteux structurés

Eric Joannet

The principal objective of this thesis is the development of a palladium catalyst supported on woven fabrics of activated carbon fibers (ACF) for the reactions of hydrogenations in liquid phase and the design of multiphase reactors using the characteristic ...

EPFL2005

An Efficient Drug Metabolism Strategy Based on Microsome-Mesoporous Organosilica Nanoreactors

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First-Principles Study of Non-heme Fe(II) Halogenase SyrB2 Reactivity

Three-Phase Catalytic Hydrogenation of a Functionalized Alkyne: Mass Transfer and Kinetic Studies with in Situ Hydrogen Monitoring

Pd Nanoparticles in a Supported Ionic Liquid Phase: Highly Stable Catalysts for Selective Acetylene Hydrogenation under Continuous-Flow Conditions

Fast temperature cycling of the catalytic CO oxidation using microstructure reactors

Forced periodic temperature cycling of chemical reactions in microstructure devices

Synthesis of monodispersed palladium nanoparticles to study structure sensitivity of solvent-free selective hydrogenation of 2-methyl-3-butyn-2-ol

Proton shuttles and phosphatase activity in soluble epoxide hydrolase

Determination of adjusted neutron spectra in different MUSE configurations by unfolding techniques

Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease

Hydrogénation sélective du 2-butyne-1,4-diol avec des catalyseurs de palladium supportés sur des matériaux filamenteux structurés

Forced periodic temperature cycling of chemical reactions in microstructure devices

Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease

Proton shuttles and phosphatase activity in soluble epoxide hydrolase

Determination of adjusted neutron spectra in different MUSE configurations by unfolding techniques

First-Principles Study of Non-heme Fe(II) Halogenase SyrB2 Reactivity

Hydrogénation sélective du 2-butyne-1,4-diol avec des catalyseurs de palladium supportés sur des matériaux filamenteux structurés

Three-Phase Catalytic Hydrogenation of a Functionalized Alkyne: Mass Transfer and Kinetic Studies with in Situ Hydrogen Monitoring

Fast temperature cycling of the catalytic CO oxidation using microstructure reactors

Synthesis of monodispersed palladium nanoparticles to study structure sensitivity of solvent-free selective hydrogenation of 2-methyl-3-butyn-2-ol

Pd Nanoparticles in a Supported Ionic Liquid Phase: Highly Stable Catalysts for Selective Acetylene Hydrogenation under Continuous-Flow Conditions