Publication
Water soluble arene-functionalised trithiolato-bridged ruthenium complexes of general formula (eta(6)-C6H5OCH2CH2OH)(2)Ru-2(mu-SR)(3), where R = C6H5 (1), C6H4-p-OMe (2), C6H4-p-OMe (3), C6H4-p-Pr-i (4), C6H4-p-Bu-t (5), CH2C6H5 (6), CH2CH2C6H5 (7) and CH2C6H4-p-Bu-t (8), were prepared from the reaction of [(eta(6)-C6H5OCH2CH2OH)(2)Ru-2(mu-Cl)(2)Cl-2] with the corresponding thiol, RSH. Complexes [1] Cl-[8]Cl were isolated in good yields as their chloride salts and they were fully characterised using spectroscopic and analytical techniques and the structures of [1]Cl, [3]Cl and [4]Cl were determined in the solid-state by single-crystal X-ray diffraction. The antiproliferative activity of [1]Cl-[8]Cl was evaluated against human ovarian cancer (A2780, A2780cisR) and non-cancerous (HEK293) cells with [4]Cl and [5]Cl being more active than cisplatin on the cancer cells and also more selective. (C) 2014 Elsevier B.V. All rights reserved.
Didier Trono, Priscilla Turelli, Sandra Eloise Kjeldsen, Evaristo Jose Planet Letschert, Filipe Amândio Brandão Sanches Vong Martins, Florian Huber, Cyril David Son-Tuyên Pulver, Olga Marie Louise Rosspopoff, Romain Forey, Joana Carlevaro Fita
Paul Joseph Dyson, Farzaneh Fadaei Tirani, Mouna Hadiji