Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Léonie Asboth, Quentin Barraud, Marco Capogrosso, Grégoire Courtine, Simone Ellen Joze Duis, Jérôme Gandar, Arthur Edouard Hirsch, Stéphanie Lacour, Eduardo Martin Moraud, Silvestro Micera, Tomislav Milekovic, Ivan Rusev Minev, Pavel Musienko, Natalia Pavlova, Nicolas Vachicouras, Nikolaus Wenger
American Association for the Advancement of Science, 2015
Article

Résumé

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.

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https://infoscience.epfl.ch/record/204534?ln=fr

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