Publication
Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Publications associées (52)
Deconstructing and Reconstructing the Complexity of Tau pathology
This thesis consists of four Chapters unified by a singular theme â how do we develop disease models that faithfully reproduce the pathology seen in patients suffering from neurodegenerative disorders associated with the Tau protein, such as Alzheimerâ ...
EPFL2023Capturing the heterogeneity of alpha-synuclein pathology in synucleinopathies
Synucleinopathies such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy (MSA) are detrimental neurodegenerative diseases. Alpha-synuclein (aSyn), the main aggregating protein found in the pathological inclusions of these ailmen ...
EPFL2022Trans‐seeding of Alzheimer‐related tau protein by a yeast prion
Henning Paul-Julius Stahlberg, Zhiva Skachokova
Abnormal tau protein aggregates constitute a hallmark of Alzheimer's disease. The mechanisms underlying the initiation of tau aggregation in sporadic neurodegeneration remain unclear. Here we investigate whether a non-human prion can seed tau aggregation. ...
2022Alpha-synuclein as a Potential Biomarker for Parkinson’s Disease and Other Synucleinopathies: Gaps, Challenges, and Opportunities
Parkinson's disease (PD), the second most common progressive neurodegenerative disease, develops and progresses for 10-15 years before the clinical diagnostic symptoms of the disease are manifested. Furthermore, several aspects of PD pathology overlap with ...
2022Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies
Hilal Lashuel, Pedro José Santana Ribeiro Magalhães
Parkinson's disease (PD), the second most common progressive neurodegenerative disease, develops and progresses for 10-15 years before the clinical diagnostic symptoms of the disease are manifested. Furthermore, several aspects of PD pathology overlap with ...
NATURE PORTFOLIO2022Augmented-reality-assisted timber drilling with smart retrofitted tools
Yves Weinand, Julien Gamerro, Andrea Settimi
An ordinary electric drill was integrated into a context-aware augmented reality (AR) framework to assist in timber-drilling tasks. This study is a preliminary evaluation to detail technical challenges, potential bottlenecks, and accuracy of the proposed o ...
2022The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation
Liquid-liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlying the formation of membrane-less organelles. Such biomolecular condensates have various biological functions and have been linked to disease. The protein F ...
OXFORD UNIV PRESS2021Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
Alteration to endoplasmic reticulum (ER) proteostasis is observed in a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteost ...
2021FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade
Henning Paul-Julius Stahlberg, Amanda Jennifer Lewis, Marta Di Fabrizio, Julien Weber
Morphologically distinct TDP-43 aggregates occur in clinically different FTLD-TDP subtypes, yet the mechanism of their emergence and contribution to clinical heterogeneity are poorly understood. Several lines of evidence suggest that pathological TDP-43 fo ...
WILEY2021Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?
More than a century has passed since pathological protein aggregates were first identified in the brains of patients with neurodegenerative diseases (NDDs). Yet, we still do not have effective therapies to treat or slow the progression of these devastating ...
2021