Neurogenesis as therapeutic target to rescue hippocampal-mediated learning and memory deficits in a mouse model of Down syndrome
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For decades, the mammalian hippocampus has been the focus of cellular, anatomical, behavioral, and computational studies aimed at understanding the fundamental mechanisms underlying cognition. Long recognized as the brain's seat for learning and memory, a ...
This paper explores a novel application of textual semantic similarity to user-preference representation for rating prediction. The approach represents a user's preferences as a graph of textual snippets from review text, where the edges are defined by sem ...
In recent decades, industrial heritage has gained notoriety among the richness of heritage narratives. However, its promotion is primarily done by the production entities and business archives, and less attention is given to the significant contribution of ...
Learning and memory rely on synaptic communication in which intracellular signals are transported to the nucleus to stimulate transcriptional activation. Memory induced transcriptional increases are accompanied by alterations to the epigenetic landscape an ...
This short essay illustrates the role of the business archive in the transmission and maintenance of contemporary industrial culture, with a focus on the company town of Dalmine. In the context of Dalmine, the business archive managed by the Fondazione Dal ...
Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...
Short-term synaptic plasticity and modulations of the presynaptic vesicle release rate are key components of many working memory models. At the same time, an increasing number of studies suggests a potential role of astrocytes in modulating higher cognitiv ...
Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and ...
The formation and storage of memories has been under deep investigation for several decades. Nevertheless, the precise contribution of each brain region involved in this process and the interplay between them across memory consolidation is still largely de ...
Diabetes impacts on brain metabolism, structure, and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. Howe ...
