Publication

Modulation of working memory duration by synaptic and astrocytic mechanisms

Sophia Becker
2022
Article
Résumé

Short-term synaptic plasticity and modulations of the presynaptic vesicle release rate are key components of many working memory models. At the same time, an increasing number of studies suggests a potential role of astrocytes in modulating higher cognitive function such as WM through their influence on synaptic transmission. Which influence astrocytic signaling could have on the stability and duration of WM representations, however, is still unclear. Here, we introduce a slow, activity-dependent astrocytic regulation of the presynaptic release probability in a synaptic attractor model of WM. We compare and analyze simulations of a simple WM protocol in firing rate and spiking networks with and without astrocytic regulation, and underpin our observations with analyses of the phase space dynamics in the rate network. We find that the duration and stability of working memory representations are altered by astrocytic signaling and by noise. We show that astrocytic signaling modulates the mean duration of WM representations. Moreover, if the astrocytic regulation is strong, a slow presynaptic timescale introduces a 'window of vulnerability', during which WM representations are easily disruptable by noise before being stabilized. We identify two mechanisms through which noise from different sources in the network can either stabilize or destabilize WM representations. Our findings suggest that (i) astrocytic regulation can act as a crucial determinant for the duration of WM representations in synaptic attractor models of WM, and (ii) that astrocytic signaling could facilitate different mechanisms for volitional top-down control of WM representations and their duration. Author summary The ability to form memories and recall them is one of the fascinating features of our brain. Working memory operates like a memory scratch pad storing ongoing information for further processing. Here, we present a computational model dissecting the influence of astrocytes on the stability and duration of working memories. We find that a long astrocytic time constant can influence the mean duration of working memory representations and generate a "window of vulnerability", during which some memories are tagged for long-term survival while some are terminated. The fraction of memories in the survival and termination groups could be regulated by adjusting the strength of astrocytic feedback or its time constant. This indicates that astrocytic signaling can be viewed as a candidate mechanism for top-down control of working memory representations and their duration.

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Concepts associés (32)
Mémoire (psychologie)
thumb|350px|Les formes et fonctions de la mémoire en sciences. En psychologie, la mémoire est la faculté de l'esprit d'enregistrer, conserver et rappeler les expériences passées. Son investigation est réalisée par différentes disciplines : psychologie cognitive, neuropsychologie, et psychanalyse. thumb|Pyramide des cinq systèmes de mémoire. Le courant cognitiviste classique regroupe habituellement sous le terme de mémoire les processus dencodage, de stockage et de récupération des représentations mentales.
Mémoire de travail
Le système cognitif fonctionne en acquérant, filtrant et traitant des informations vitales, utiles, potentiellement utiles à court, moyen et long termes ; il a donc besoin de stocker (mémoriser) ces informations. Le cerveau semble pour cela disposer de systèmes différents, mais complémentaires, de mémoire à long terme et de mémoire à court terme. La notion de mémoire de travail, apparue dans les années 1970 désigne .
Astrocyte
Les astrocytes sont des cellules gliales du système nerveux central. Elles ont généralement une forme étoilée, d'où provient leur étymologie (origine grec) : Astro - étoile et cyte - cellule. Elles assurent une diversité de fonctions importantes, centrée sur le support et la protection des neurones. Ces cellules participent au maintien de la barrière hémato-encéphalique, régulent le flux sanguin, assurent l'approvisionnement en nutriments et le métabolisme énergétique du système nerveux, participent à la neurotransmission, à la détoxification du milieu extracellulaire notamment par capture du glutamate, et maintiennent la balance ionique du milieu extracellulaire.
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