The Cu-catalyzed synthesis of skipped 1,4-dienes from allylic acetates and vinyl-Grignard reagents is key to bidirectional modifications of acyclic terpene acetates. As a result, trisubstituted double bond containing subunits can be readily transferred into complex polyketides from inexpensive bulk terpenes.
Mirjana Stojilovic, Seyedeh Sharareh Mirzargar, Zeinab Seifoori
Ursula Röthlisberger, Siri Camee van Keulen, Daniele Narzi
Bryan Alexander Ford, Linus Gasser, Eleftherios Kokoris Kogias