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Photoinduced Nonpersistent Radicals as Polarizing Agents for X-Nuclei Dissolution Dynamic Nuclear Polarization

Publications associées (34)

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129Xe Dynamic Nuclear Polarization Demystified: The Influence of the Glassing Matrix on the Radical Properties

Rolf Gruetter, Andrea Capozzi, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê, Emma Linnea Wiström

129Xe dissolution dynamic nuclear polarization (DNP) is a controversial topic. The gold standard technique for hyperpolarized xenon magnetic resonance imaging (MRI) is spin exchange optical pumping, which received FDA approval in 2022. Nevertheless, the ve ...

2024

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The sensitivity of NMR spectroscopy is considerably enhanced by dynamic nuclear polarization (DNP). In DNP polarization is transferred from unpaired electrons of a polarizing agent to nearby proton spins. In solids, this transfer is followed by the transpo ...

2023

Single Chip Dynamic Nuclear Polarization Microsystems

Nergiz Sahin Solmaz

Nuclear magnetic resonance (NMR) methods are powerful tools employed in many fields, including physics, chemistry, material science, biology, and medicine. The use of NMR methodologies in an even wider range of applications is often hindered by the relativ ...

EPFL2023

Multi-sample/multi-nucleus parallel polarization and monitoring enabled by a fluid path technology compatible cryogenic probe for dissolution dynamic nuclear polarization

Andrea Capozzi, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê

Low throughput is one of dissolution Dynamic Nuclear Polarization (dDNP) main shortcomings. Especially for clinical and preclinical applications, where direct 13C nuclei polarization is usually pursued, it takes hours to generate one single hyperpolarized ...

2023

Performance and reproducibility of C-13 and N-15 hyperpolarization using a cryogen-free DNP polarizer

Hikari Ananda Infinity Yoshihara, Arianna Ferrari

The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using ...

NATURE PORTFOLIO2022

Methods to Enhance Nuclear Magnetic Resonance Sensitivity at High Magnetic Field

Claudia Christina Zanella

MR is a well-established technique routinely used in preclinical and clinical studies. This thesis focussed on the improvement of sensitivity of different methods in MR. Hyperpolarized 129Xe gas is used for studying pulmonary disease or cerebral perfusion ...

EPFL2021

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Identifying and characterizing systems that generate well-defined states with large electron spin polarization is of high interest for applications in molecular spintronics, high-energy physics, and magnetic resonance spectroscopy. The generation of electr ...

2020

UV-Irradiated 2-Keto-(1-C-13)Isocaproic Acid for High-Performance C-13 Hyperpolarized MR

Andrea Capozzi, Arthur César Pinon

Enhancing the sensitivity of magnetic resonance spectroscopy/imaging (MRS/MRI) by dissolution dynamic nuclear polarization (dDNP) has expanded the scope of MRS applications to new fields of research. Most importantly, it has paved the way toward noninvasiv ...

AMER CHEMICAL SOC2020

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Hyperpolarization in diamond via dynamic nuclear polarization (DNP) has attracted a lot of interest for various applications as diamond exhibits extremely long C-13 spin relaxation times and has endogenous polarizing agents in the form of crystalline defec ...

2019

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Purpose To probe the cardiac metabolism of carbohydrates and short chain fatty acids simultaneously in vivo following the injection of a hyperpolarized 13C-labeled substrate mixture prepared using photo-induced nonpersistent radicals. Methods Droplets of m ...

2018