Publication

The Developmental Control of Transposable Elements and the Evolution of Higher Species

Publications associées (162)

Complete genome sequence of the sulfate-reducing Firmicute Desulfotomaculum ruminis type strain (DLT)

Desulfotomaculum ruminis Campbell and Postgate 1965 is a member of the large genus Desulfotomaculum which contains 30 species and is contained in the family Peptococcaceae. This species is of interest because it represents one of the few sulfate-reducing b ...

Genomic Stand Consort2012

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

Didier Trono, Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen, Anna Claire Groner

The study of chromatin and its regulators is key to understanding and manipulating transcription. We previously exploited the Krüppel-associated box (KRAB) transcriptional repressor domain, present in hundreds of vertebrate-specific zinc finger proteins, t ...

2012

Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

The developmental potential of human pluripotent stem cells suggests that they can produce disease-relevant cell types for biomedical research. However, substantial variation has been reported among pluripotent cell lines, which could affect their utility ...

2011

In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions

Didier Trono, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Andrea Corsinotti, Johan Jakobsson

The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3 ...

Elsevier2011

Unique Cell-Type-Specific Distributions and Functions of Brain MicroRNAs

Ana Jovicic

MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene expression. The first miRNA was discovered less than 20 years ago in the context of studying Caenorabditis elegans development. The discovery of the second miR ...

EPFL2011

Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences

Didier Trono, Isabelle Barde, Sonia Verp, Marc Samuel Friedli

Comparative analyses of various mammalian genomes have identified numerous conserved non-coding (CNC) DNA elements that display striking conservation among species, suggesting that they have maintained specific functions throughout evolution. CNC function ...

Public Library of Science2011

Dynamic control of endogenous retroviruses during development

Didier Trono, Helen Mary Rowe

Close to half of the human genome encompasses mobile genetic elements, most of which are retrotransposons. These genetic invaders are formidable evolutionary forces that have shaped the architecture of the genomes of higher organisms, with some conserving ...

Elsevier2011

Presentation and study of robustness for several methods to classify individuals based on their gene expressions

Julien Damond

Several studies have shown that it is possible to detect cancer tissues based on gene expressions using methods of machine learning. The main problem with classifying gene expression data is to obtain accurate rules that are easy to interpret and provide i ...

2011

ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor

Debora Keller

We have previously reported that RAS-MEK (Cancer Res. 2003 May 1;63(9):2088-95) and TGF-β (Cancer Res. 2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell-surface expression and adenovirus uptake. In t ...

BioMed Central2011

Extent and Patterns of MGMT Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres

Purpose: Quantitative methylation-specific tests suggest that not all cells in a glioblastoma with detectable promoter methylation of the O6-methylguanine DNA methyltransferase (MGMT) gene carry a methylated MGMT allele. This observation may indicate cell ...

2011

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