Signal transduction networks: topology, response and biochemical processes
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One of the basic characteristics of every living system is the ability to respond to extracellular signals. This is carried out through a limited number of protein-based signaling networks, whose function is not based only on simple transmission of the rec ...
One of the basic characteristics of every living system is the ability to respond to extracellular signals. This is carried out through a limited number of protein-based signaling networks, whose function is not only based on simple transmission of the rec ...
The tyrosine kinase Bcr-Abl causes chronic myeloid leukemia and is the cognate target of tyrosine kinase inhibitors like imatinib. We have charted the protein-protein interaction network of Bcr-Abl by a 2-pronged approach. Using a monoclonal antibody we ha ...
Providing real-time multimedia services over a best-effort network is challenging due to the stringent delay requirements in the presence of complex network dynamics. Multiple description (MD) coding is one approach to transmit the media over diverse (mult ...
The framework of complex networks has been shown to describe adequately a wide class of complex systems made up of a large number of interacting units. In this framework, a node is associated to each unit and two nodes are connected by an edge if the two u ...
Purpose: Apoptosis is known to play a key role in cell death after retinal ischemia. However, little is known about the kinetics of the signaling pathways involved and their contribution to this process. The aim of this study was to determine whether chang ...
We developed an in vitro protein expression and interaction analysis platform based on a highly parallel and sensitive microfluidic affinity assay, and used it for 14,792 on-chip experiments, which exhaustively measured the protein-protein interactions of ...
Organizations exploit the information diffusion and signaling properties of their existing inter-organizational networks to manage the risks and uncertainty involved in forming new partnerships. How then do new organizations that are unknown to existing ne ...
Odontogenesis is governed by a complex network of intercellular signaling events between the dental epithelium and mesenchyme. This network leads to the progressive determination of tooth shape, and to the differentiation of these tissues into enamel-produ ...
Plasmodium falciparum is a deadly parasite that causes malaria in humans. This disease causes the death of one million people every year. To find new means to fight this parasite, it is important to learn more about its biology. As the pathways of protein ...
