Access to Chiral Cyclopentane Scaffolds by Enantioselective Nickel-Catalyzed Annulations
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Oxidative addition of BrC CC(=O)O-menthyl (1a) to [Pd(PPh3)(4)] affords the alkynyl complex trans-[Br(PPh3)(2)Pd-C CC(=O)O-menthyl] (2a). Subsequent reaction of 2a with trifluoroacetate gives trans-[(F3CCOO)(PPh3)(2)Pd-C CC(=O)O-menthyl] (3a). Reaction of ...
This thesis is divided in seven main chapters including an introduction about the state of the art in the field, four main chapters describing the main part of the work, a short insight on the implications of the presented results for other research projec ...
The goal of this thesis is to develop new carbon-carbon bond forming reactions using inexpensive and simple coupling partners like aryl halides (pseudohalides), sulfonyl derivatives, Grignard reagents, alkenes and alkynes with metal catalysis, preferably u ...
Non-activated alkyl halides are challenging substrates for cross-coupling reactions because they are reluctant to undergo oxidative addition and because metal alkyl intermediates are prone to β-H elimination. Despite recent progress, well-defined catalysts ...
The β-diketiminate class of ligands is renowned for the stabilization of coordinatively unsatd. main-group and transition metal complexes. Moreover, the application and scope of transition metal β-diketiminate complexes in the catalytic transformation of o ...
Carbon-carbon bond forming reactions are among the most important and useful methods for organic synthesis. During the last years, significant progress has been made in this field. Whereas many catalysts were developed for the coupling of aryl, alkenyl, an ...
A general and straightforward protocol for the cross-coupling of non-activated alkyl halides with heterocyclic CH bonds has been developed. The transformation is chemo- and regioselective and many functional groups on both coupling partners are tolerated. ...
In organic synthesis, cyclopropanation reactions are often performed with Simmons Smith-type reagents or by transition metal catalyzed reactions of olefins with diazo compounds. A novel method for the synthesis of substituted cyclopropanes is described tha ...
Metal complexes bearing phosphine ligands are attracting increasing attention for their applications in medicinal chem. In particular, organometallic ruthenium-phosphine complexes have been found to exhibit promising antitumor activity. The synthesis, anti ...
Rhodium(I)-catalyzed C-H functionalization of aryl ketimines and subsequent carborhodation of a terminal allene resulted in the formation of allyl rhodium intermediates, which underwent allylation of the imine to give cyclized products, e.g., I, with high ...