Adjuvant-Loaded Subcellular Vesicles Derived From Disrupted Cancer Cells for Cancer Vaccination

Immunogenic subcellular vesicular particles that can be used to stimulate antigen-specific immune responses in vitro and in vivo are generated from whole cancer cells. The particles retain a broad antigen repertoire similar to that of the parent cells, and can be loaded with disparate adjuvant payloads. These particles may represent a superior alternative to lysate, the standard for primary antigen preparations, in various cancer vaccine applications.