ReuptakeReuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse. Reuptake is necessary for normal synaptic physiology because it allows for the recycling of neurotransmitters and regulates the level of neurotransmitter present in the synapse, thereby controlling how long a signal resulting from neurotransmitter release lasts.
PsychopharmacologiePsychopharmacology (from Greek psȳkhē; pharmakon; and -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, behavior, judgment and evaluation, and memory. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior. The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.
Opioid antagonistAn opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors. Naloxone and naltrexone are commonly used opioid antagonist drugs which are competitive antagonists that bind to the opioid receptors with higher affinity than agonists but do not activate the receptors. This effectively blocks the receptor, preventing the body from responding to opioids and endorphins.
Syndrome douloureux régional complexeLe syndrome douloureux régional complexe (SDRC) est un état pathologique caractérisé par un syndrome associant des douleurs et d'autres symptômes touchant typiquement une extrémité après un traumatisme ou une intervention chirurgicale même minime. Ce syndrome pourrait être dû à des causes neurologiques, notamment une dysfonction des fibres de petit calibre des nerfs périphériques - qui protègent des stimulations douloureuses et thermiques et/ou de grand calibre qui détectent les stimulations tactiles.
ImmunocytochimieL’immunocytochimie est une méthode d’analyse des cellules in situ par une technique d’immunofluorescence. Une technique immunochimique dont l'échantillon est une préparation cytologique. L'immunocytochimie permet de révéler et cibler une molécule biologique à l’échelle cellulaire depuis des anticorps spécifiques. Pour mettre en évidence ce complexe antigène-anticorps, on peut schématiser très simplement cette réaction, par : d’un côté, l’antigène que l’on veut localiser : et l’anticorps primaire spécifique, qui va se fixer sur l’antigène (s'il le trouve).
ImmunostainingIn biochemistry, immunostaining is any use of an antibody-based method to detect a specific protein in a sample. The term "immunostaining" was originally used to refer to the immunohistochemical staining of tissue sections, as first described by Albert Coons in 1941. However, immunostaining now encompasses a broad range of techniques used in histology, cell biology, and molecular biology that use antibody-based staining methods.
