Publication

In vitro modeling of complex microenvironmental regulation of stem cells

Publications associées (431)

Development of a positive and negative drug selection system towards gene correction in medaka fish haploid ES cells

This project aimed to develop an improved positive-negative selection system for potential use in basic research and clinical applications. The NTR-CB1954 system was chosen, where introduced expression of the E. Coli derived gene product nitroreductase (NT ...

2010

Embryonic stem cell-like cells established by culture of adult ovarian cells in mice

Seung Tae Lee

Objective: To suggest an alternative strategy for deriving histocompatible stems cells without undertaking genetic manipulation. ...

2010

Additive and global functions of HoxA cluster genes in mesoderm derivatives

Denis Duboule, Freddy Radtke, Ute Koch

Hox genes encode transcription factors that play a central role in the specification of regional identities along the anterior to posterior body axis. In the developing mouse embryo, Hox genes from all four genomic clusters are involved in range of develop ...

Elsevier2010

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

Maria del Carmen Sandi Perez, Hilal Lashuel, Hajer Ouertatani-Sakouhi

Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokin ...

Nature Publishing Group2010

Marker-independent identification of glioma-initiating cells

Rolf Gruetter, Cristina Ramona Cudalbu

Tumor-initiating cells with stem cell properties are believed to sustain the growth of gliomas, but proposed markers such as CD133 cannot be used to identify these cells with sufficient specificity. We report an alternative isolation method purely based on ...

Nature Publishing Group2010

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

Richardus Houtkooper

The BH3-only BID (BH3-interacting domain death agonist) protein has a critical function in the death-receptor pathway in the liver by triggering mitochondrial outer membrane permeabilization (MOMP). Here we show that MTCH2/MIMP (mitochondrial carrier homol ...

2010

Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics

Cathrin Brisken, Lucia Jimenez Rojo

Amphiregulin (AREG), a ligand for epidermal growth factor receptor, is required for mammary gland ductal morphogenesis and mediates estrogen actions in vivo, emerging as an essential growth factor during mammary gland growth and differentiation. The COMMA- ...

Elsevier2010

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

Matthias Lütolf, Nora Leonardi

Freshly isolated muscle stem cells (MuSCs) exhibit robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a novel highly autom ...

2010

Biomechanical Induction of Hematopoiesis

Olaia Maria Naveiras Torres-Quiroga

The present invention provides methods and compositions for increasing the hematopoietic potential of a population of hematopoietic progenitor cells, vascular cells, and or hemogenic endothelium, by exposing the cells to at least one external biomechanical ...

2010

A micro CT technique to measure peri-implant micromotions of cementless femoral stems

Dominique Pioletti, Alexandre Terrier, Miguel Gortchacow

The interfacial micromotion is closely associated to the long-term success of cementless hip prostheses. Various techniques have been proposed to measure them, but only a limited number of points over the stem surface can be measured simultaneously. In thi ...

2010

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