Publication

Design of a Passive Flow Regulator Using a Genetic Algorithm

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Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

Gilles Fourestey

BackgroundImpaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve (ON), including Alzheimer's and Parkinson's disease, as well as frontotemporal dementia ...

London2024

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Fluidic systems enable actuation in various applications, such as automotive, medical, and industrial robotics. Miniaturized valves constitute a fundamental controlling element of modern fluidic systems, intriguing the interest of many researchers. This le ...

2023

LES and wind tunnel studies have shown significant benefit when allowing turbines (T) in a wind farm to adopt different heights. This work presents two new genetic algorithms (GA) that perform wind farm layout optimization (WFLO) involving continuous and t ...

2022

In flow acoustic characterisation of a 2D active liner with local and non local strategies.

Hervé Lissek, Maxime Volery, Gaël Matten

The design and the grazing flow aeroacoustical characterization of a 2D active liner based on an array of electroacoustic absorbers are presented in this paper. The strategy stands on a pressure-based, current-driven digital architecture for impedance cont ...

2022

We investigate the quasi-static growth of a fluid-driven frictional shear crack that propagates in mixed mode (II+III) on a planar fault interface that separates two identical half-spaces of a three-dimensional solid. The fault interface is characterized b ...

2021

Planar hydrodynamic traps and buried channels for bead and cell trapping and releasing

Philippe Renaud, Arnaud Bertsch, Daniel Migliozzi, Clémentine Sophie Sarah Lipp, Jonathan Bastien Cottet

We present a novel concept for the controlled trapping and releasing of beads and cells in a PDMS microfluidic channel without obstacles present around the particle or in the channel. The trapping principle relies on a two-level microfluidic configuration: ...

ROYAL SOC CHEMISTRY2021

Nanopores are nanometer sized openings that are the connection between two electrolyte filled reservoirs. The measurement of the ion transport flowing through such a pore allows to probe physically or biologically interesting phenomena. These range from th ...

EPFL2020

Microfluidics of binary liquid mixtures with temperature-dependent miscibility

Esther Amstad, Stefan Guldin

Liquid-liquid microfluidic systems rely on the intricate control over the fluid properties of either miscible or immiscible mixtures. Herein, we report on the use of partially miscible binary liquid mixtures that lend their microfluidic properties from a h ...

ROYAL SOC CHEMISTRY2020

A genetic algorithm based design and experimental characterization of a highly thermostable metalloprotein

Ursula Röthlisberger, Rudolf Hovius, Marta Andreia Da Silva Perez, Esra Bozkurt, Nicholas John Browning

The development of thermostable and solvent-tolerant metalloproteins is a long-sought goal for many applica- tions in synthetic biology and biotechnology. In this work, we were able to engineer a highly thermo- and organic solvent- stable metallo variant o ...

2018

Intensifying cavitating flows in microfluidic devices with poly(vinyl alcohol) (PVA) microbubbles

Luis Guillermo Villanueva Torrijo, Morteza Ghorbani

Cavitation and the energy associated with the collapse of resulting cavitation bubbles constitute an important research subject. The collapse of the hydrodynamic cavitation bubbles at the outlet of the flow elements leads to a high energy release and gener ...

2018