Publication
Embryonic expression and activity of doughnut, a second RYK homolog in Drosophila
Publications associées (32)
Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo
Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the dev ...
Berlin2023In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture
In humans, mice, and other mammals key internal organs such as the gut, the lungs, the pancreas, and the liver all derive from the same embryonic tissue: the endoderm. The development of all of these structures thus depends on a same set of early cells, an ...
EPFL2022Targeted search for scaling genes reveals matrix metalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos
How embryos scale patterning according to size is still not fully understood. Through in silico screening and analysis of reaction-diffusion systems that could be responsible for scaling, we predicted the existence of genes whose expression is sensitive to ...
2022KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos
Transposable elements (TEs), also called jumping genes, are genetic elements capable of changing their position within the genome of their host. They make up large fractions of genomes, including 45% of human DNA content, according to current estimates.
S ...
EPFL2021In vitro modeling of early mouse development
Previous attempts to recapitulate embryogenesis in a developmentally relevant context started with aggregates composed of a few thousand ESCs, termed embryoid bodies (EB), that upon induction of differentiation reveal a surprising level of autonomous cell ...
EPFL2020Unequal cleavage of the C. elegans zygote ensures robust embryogenesis
Asymmetric cell divisions play key roles in generating cellular diversity during embryogenesis, and in tissue homeostasis during postembryonic life. Particular asymmetric cell divisions producing differentially sized daughter cells were described in many s ...
EPFL2020The melanization reaction in Drosophila: More than black or white
The melanization reaction is a rapid and important immune mechanism in arthropods. It results in the production of melanin at the site of injury and around invading microbes. The enzymes responsible for melanogenesis are phenoloxidases (PO), which catalyze ...
EPFL2018The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units
Didier Trono, Julien Léonard Duc, Marco Cassano, Michaël Imbeault, Gabriela Ecco, Annamaria Kauzlaric
KRAB-containing poly-zinc finger proteins (KZFPs) constitute the largest family of transcription factors encoded by mammalian genomes, and growing evidence indicates that they fulfill functions critical to both embryonic development and maintenance of adul ...
Public Library of Science2017Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation
TAF4 (TATA-binding protein-associated factor 4) and its paralogue TAF4b are components of the TFIID core module. We inactivated the murine Taf4a gene to address Taf4 function during embryogenesis. Here we show that Taf4a(-/-) embryos survive until E9.5 whe ...
Nature Publishing Group2016From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation
Whiskers (also known as vibrissae) are sensory organs that are thought to have first appeared in Therapsida, a group of synapsids that includes mammals and evolutionary ancestors like the Thrinaxodon(1). They are highly conserved among mammals to the notab ...
EPFL2016