Publication

Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups

Publications associées (32)

Highly efficient production of the Alzheimer's γ-Secretase integral membrane protease complex by a multi-gene stable integration approach

Florian Maria Wurm, David Hacker, Lorène Aeschbach, Patrick Fraering, Mitko Dimitrov, Sowmya Balasubramanian

Inefficient production of membrane-embedded multi-protein complexes by conventional methods has largely prevented the generation of high-resolution structural information and the performance of high-throughput drug discovery screens for this class of prote ...

2013

Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

Hatice Altug, Arif Engin Cetin, Min Huang

Effective analyte delivery is essential to achieve rapid and sensitive biodetection systems. In this article, we present an actively controlled fluidic system integrated with a suspended plasmonic nanohole sensor to achieve superior analyte delivery effici ...

2013

Decoupling of Magnetic Resonance Signals in Time and Frequency Domain

Nuclear magnetic resonance (NMR) was discovered in the first half of the 20th century. Today, neither analytical chemistry without NMR spectroscopy nor medical diagnostics without magnetic resonance imaging (MRI) could be imagined. A magnetic resonance sig ...

EPFL2013

Cell bead based three-dimensional (3D) hepatic model toward high throughput drug-induced toxicity screening

Nathalie Brandenberg

For several decades, hepatotoxicity has been a major issue for drug development.Recently, three-dimensional (3D) cell culture has been believed to improve cell drug response accuracy. However important limitations such as slow production, lack of cell dens ...

2011

Long-lived states to sustain hyperpolarized magnetization

Geoffrey Bodenhausen, Jean-Philippe Ansermet, Arnaud Comment, Sami Jannin, Paul Romeo Vasos, Riddhiman Sarkar, Puneet Ahuja

Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization (DNP) couples nuclear spins to the large reserv ...

2009

The OptoMEA platform: a new tool combining local chemical stimulation with distributed multi-electrode array recordings

Diego Ghezzi, Marc Olivier Heuschkel, Solomzi Makohliso

We present a novel OptoMEA platform that combines multisite electrical recording with local chemical stimulation. Applying UV light pulses through an array of optical fibres aligned to transparent indium-tin oxide electrodes of an MEA biochip leads to loca ...

2008

Nuclear Spin Relaxation Parameters of MRI Contrast Agents – Insight from Quantum Mechanical Calculations

Lothar Helm, Oleg Yazyev

Nuclear magnetic relaxation in the presence of paramagnetic centres has gained increasing interest in recent years partly due to its importance for contrast agents in magnetic resonance imaging. Rational design of new more efficient agents is possible as a ...

Wiley-Blackwell2008

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

Oleg Yazyev

The phenomenon of magnetism is one of the key components of today's technological progress. Magnetic interactions and magnetic materials are essential for the scientific disciplines of physics, chemistry and biology, making this subject truly multidiscipli ...

EPFL2007

Stochastic Liouville equation treatment of the electron paramagnetic resonance line shape of an S-state ion in solution

Alain Borel

The current approaches used for the analysis of electron paramagnetic resonance spectra of Gd3+ complexes suffer from a number of drawbacks. Even the elaborate model of [Rast et al., J. Chem. Phys. 113, 8724 (2000)] where the electron spin relaxation is ex ...

2007

Fluorescence Correlation Spectroscopy of Molecular Motions and Kinetics

The foundations for fluorescence correlation spectroscopy (FCS) were already laid in the early 1970s, but this technique did not become widely used until single-molecule detection was established almost 20 years later with the use of diffraction-limited co ...

2005

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