Reprogramming tumor blood vessels for enhancing immunotherapy

Michele De Palma
2017
Article

Résumé

Angiogenic blood vessels contribute to generating an immunosuppressive tumor microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other cancer immunotherapies.

Source officielle

https://infoscience.epfl.ch/record/231798?ln=fr

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