Publication

A multiscale study of the role of dynamin in the regulation of glucose uptake

Publications associées (82)

Hepatic glucose sensing is required to preserve β cell glucose competence

Rolf Gruetter, Bernard Lanz, Frédéric Schütz, Carole Poitry-Yamate

Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice). Loss of Glut2 suppr ...

Amer Soc Clinical Investigation Inc2013

An acetylation rheostat for the control of muscle energy homeostasis

Johan Auwerx, Keir Joe Menzies

In recent years, the role of acetylation has gained ground as an essential modulator of intermediary metabolism in skeletal muscle. Imbalance in energy homeostasis or chronic cellular stress, due to diet, aging, or disease, translate into alterations in th ...

Society for Endocrinology2013

Autophagy Defect Is Associated with Low Glucose-Induced Apoptosis in 661W Photoreceptor Cells

Johan Auwerx, Pénélope Andreux, Martine Emery

Glucose is an important metabolic substrate of the retina and diabetic patients have to maintain a strict normoglycemia to avoid diabetes secondary effects, including cardiovascular disease, nephropathy, neuropathy and retinopathy. Others and we recently d ...

Public Library of Science2013

Comparative Performance of Different Nanostructured Electrochemical Sensors on Insulin Detection

Giovanni De Micheli, Sandro Carrara, Lucia Grassi

New advancements in the management of type I diabetic patients (T1DM) call for a new generation of monitoring systems based upon an array of metabolic biosensors including sensors for insulin detection. Blood insulin values are always less than 270 pM; the ...

2013

Brain Glucose Transport and Phosphorylation Under Acute Insulin-Induced Hypoglycemia in Mice: An 18F-FDG PET Study

Rolf Gruetter, João Miguel das Neves Duarte, Malte Alf

We addressed the questions of how cerebral glucose transport and phosphorylation change under acute hypoglycemia and what the underlying mechanisms of adaptation are. Methods: Quantitative 18F-FDG PET combined with the acquisition of real-time arterial inp ...

2013

A Viscosity-Dependent Affinity Sensor for Continous Monitoring of Glucose in Biological Fluids

Christophe Boss

For fifty years, tremendous efforts have been directed towards the development of glucose sensors for tight glycemic control of diabetic patients. Today, millions of diabetics test their blood glucose level daily, making glucose the most commonly tested an ...

EPFL2012

Engineered insulin-like growth factor-1 for improved smooth muscle regeneration

Peter Frey, Jeffrey Alan Hubbell, Kristen Lorentz, Lirong Yang

Insulin-like growth factor-1 (IGF-1) has been shown to induce potent mitogenic responses in various cell types, yet its sustained local delivery is still an underdeveloped domain in the clinic. We report here an engineered IGF-1 that facilitates extended l ...

2012

Increasing the sensitivity of enzyme-based biosensors using copper-chloride and EDTA

Nico de Rooij, Peter Van der Wal, Sara Talaei

The effect of CuCl2 and EDTA on increasing the sensitivity of enzyme biosensors was evaluated. The experiments revealed that successive exposure of these solutions to our biosensors can increase the sensitivity of the glucose and lactate biosensors up to 8 ...

2012

JewelPUMP (TM) by Debiotech S.A.: Insulin Temperature Measurement Study

Adrien De Muralt

For type 1 Diabetes, insulin injection therapy is the most used treatment today, and insulin pumps are surely the most accurate therapeutic strategy. The insulin use temperature has to not exceed 37°C to prevent unwanted degradation and loss of function. T ...

2011

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

Johan Auwerx, Hiroyasu Yamamoto

Insulin resistance, tissue inflammation, and adipose tissue dysfunction are features of obesity and Type 2 diabetes. We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice to investigate the function of NCoR in adipocyte bi ...

2011

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