Publication
Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
Publications associées (33)
Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo
Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...
EPFL2017How Energy Metabolism Supports Cerebral Function: Insights from 13C Magnetic Resonance Studies In vivo
Rolf Gruetter, João Miguel das Neves Duarte, Sarah Catherine Sonnay
Cerebral function is associated with exceptionally high metabolic activity, and requires continuous supply of oxygen and nutrients from the blood stream. Since the mid-20th century the idea that brain energy metabolism is coupled to neuronal activity has e ...
Frontiers Research Foundation2017On the Origin of Individual Functional Connectivity Variability: The Role of White Matter Architecture
Gabriel Girard, Maxime Descoteaux
Fingerprint patterns derived from functional connectivity (FC) can be used to identify subjects across groups and sessions, indicating that the topology of the brain substantially differs between individuals. However, the source of FC variability inferred ...
2017Advanced magnetic resonance spectroscopy and imaging techniques applied to brain development and animal models of perinatal injury
Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) are widely used in the field of brain development and perinatal brain injury. Due to technical progress the magnetic field strength (B0) of MR systems has continuously increased, fa ...
Elsevier2015Task-Driven Activity Reduces the Cortical Activity Space of the Brain: Experiment and Whole-Brain Modeling
How a stimulus or a task alters the spontaneous dynamics of the brain remains a fundamental open question in neuroscience. One of the most robust hallmarks of task/stimulus-driven brain dynamics is the decrease of variability with respect to the spontaneou ...
Public Library Science2015Brain energy metabolism measured by 13C magnetic resonance spectroscopy in vivo upon infusion of [3-13C]lactate
Rolf Gruetter, João Miguel das Neves Duarte, Freya-Merret Girault
The brain uses lactate produced by glycolysis as an energy source. How lactate originated from the blood stream is used to fuel brain metabolism is not clear. The current study measures brain metabolic fluxes and estimates the amount of pyruvate that becom ...
Wiley-Blackwell2015Connectivity Analysis of Brain States and Applications in Brain-Computer Interfaces
Human brain is organized by a large number of functionally correlated but spatially distributed cortical neurons. Cognitive processes are usually associated with dynamic interactions among multiple brain regions. Therefore, the understanding of brain funct ...
EPFL2015White Matter Integrity of Specific Dentato-Thalamo-Cortical Pathways is Associated with Learning Gains in Precise Movement Timing
Friedhelm Christoph Hummel, Maximilian Jonas Wessel
The dentato-thalamo-cortical tract (DTCT) connects the lateral cerebellum with contralateral motor and nonmotor areas, such as the primary motor cortex (M1), the ventral premotor cortex (PMv), and the dorsolateral prefrontal cortex (DLPFC). As the acquisit ...
Oxford University Press2015In Vivo Magnetic Resonance Spectroscopy (MRS) of the Activated Human Brain at 7T
The principal aim of this thesis was to investigate human brain energy metabolism during physiological activation using proton (1H) magnetic resonance spectroscopy (MRS) at 7 Tesla (T). High magnetic fields (≥ 7 T) provide several advantages in human brain ...
EPFL2013Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla
Rolf Gruetter, Lijing Xin, Nicolas Kunz, Benoît Schaller
After the landmark studies reporting changes in the cerebral metabolic rate of glucose (CMR(Glc) ) in excess of those in oxygen (CMR(O2) ) during physiological stimulation, several studies have examined the fate of the extra carbon taken up by the brain, r ...
Wiley-Blackwell2013