Publication
Feasibility of in vivo measurement of glucose metabolism in the mouse hypothalamus by (1) H-[(13) C] MRS at 14.1T
Publications associées (69)
Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate-glutamine cycle in the tree shrew visual cortex
Rolf Gruetter, Gregor Rainer, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay, Anne Catherine Clerc
Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple t ...
Wiley-Blackwell2018Glycogen Supercompensation in the Rat Brain After Acute Hypoglycemia is Independent of Glucose Levels During Recovery
Rolf Gruetter, João Miguel das Neves Duarte
Patients with diabetes display a progressive decay in the physiological counter-regulatory response to hypoglycemia, resulting in hypoglycemia unawareness. The mechanism through which the brain adapts to hypoglycemia may involve brain glycogen. We tested t ...
Springer Verlag2017Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo
Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...
EPFL2017Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized C-13 magnetic resonance
Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment
The mammalian brain relies primarily on glucose as a fuel to meet its high metabolic demand. Among the various techniques used to study cerebral metabolism, C-13 magnetic resonance spectroscopy (MRS) allows following the fate of C-13-enriched substrates th ...
Springer Nature2017Mediatorless, Reversible Optical Nanosensor Enabled through Enzymatic Pocket Doping
Ardemis Anoush Boghossian, Benjamin Paul Johanès Gabriel Lambert, Vitalijs Zubkovs, Esra Ahunbay
This study presents a reversible, mediatorless, near-infrared glucose sensor based on glucose oxidase-wrapped SWCNTs. A combination of fluorescence, absorption, and Raman spectroscopy measurements suggest a fluorescence enhancement mechanism based on local ...
Wiley-Blackwell2017Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage
Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy m ...
Frontiers Media Sa2016New optical tools for non-invasive imaging and quantification of glucose and nicotinamide riboside in living cells and animals
Glucose is one of the most important metabolites that plays a key role in living organisms, as it is the primary energy source. Glucose metabolism is also an integral part in the pathogenesis of diabetes and cancer. Despite this tremendous impact of glucos ...
EPFL2016Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose
Anders Meibom, Graham Knott, Stéphane Laurent Escrig, Arnaud Comment, Yuhei Takado, Mojgan Masoodi
Glucose is the primary source of energy for the brain but also an important source of building blocks for proteins, lipids, and nucleic acids. Little is known about the use of glucose for biosynthesis in tissues at the cellular level. We demonstrate that l ...
Elsevier2015Hepatic glucose sensing and integrative pathways in the liver
Kristina Schoonjans, Maaike Hélène Oosterveer
The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic glycemia. Here we review the recent literature on its components and metabolic actions. ...
Springer Basel Ag2014Dissecting the Effects of Concentrated Carbohydrate Solutions on Protein Diffusion, Hydration, and Internal Dynamics
Matteo Dal Peraro, Luciano Andres Abriata, Francesco Piazza, Enrico Spiga
We present herein a thorough description of the effects of high glucose concentrations on the diffusion, hydration and internal dynamics of ubiquitin, as predicted from extensive molecular dynamics simulations on several systems described at fully atomisti ...
Amer Chemical Soc2014