Impact of individual differences in glucocorticoid adaptation to stress on behavior, neurophysiology and metabolism
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Aims The implantable loop recorder (ILR) continuously monitors the heart’s electric activity by means of a subcutaneous bipolar electrogram (Elg). Currently, the relationship between the Elg and the surface electrocardiogram (ECG) has been poorly documente ...
The vitamin D(3) and nicotine (VDN) model is a model of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of ...
In this thesis we study ventricular-arterial coupling in rodents under the influence of arterial stiffening and myocardial infarction (MI), combination of the two considered as a novel cardiovascular research model for diseased hearts pumping against an ag ...
The cardiovascular system can be macro-modelled as a collection of coupled oscillators. Recently, the use of mutual couplings of these oscillators to characterize the state of the system during anaesthesia has been proposed. Assuming that the synchronizati ...
The peroxisome proliferator-activated receptor-alpha (PPARalpha) plays a major role in the control of cardiac energy metabolism. The role of PPARalpha on cardiac functions was evaluated by using PPARalpha knockout (PPARalpha -/-) mice. Hemodynamic paramete ...
GLUT8 is a glucose transporter isoform expressed at high levels in testis; at intermediate levels in the brain, including the hippocampus; and at lower levels in the heart and several other tissues. GLUT8 is located in an intracellular compartment and does ...
We explored here the possibility that mid-life stress in rats could have deleterious effects on cognitive abilities during early aging, as well as the potential role of inter-individual differences on the development of such effects. Male Wistar rats were ...
In this work we present a mathematical model for the coupling of cardiovascular system and metabolism under sport efforts. Effects such as oxygenation, heart rates, flow rates, blood pressure and mass transfer to tissues will be considered. A special atten ...
The cardiovascular system can be macro-modelled as a collection of coupled oscillators. Recently, the use of mutual couplings of these oscillators to characterize the state of the system during anaesthesia has been proposed. Assuming that the synchronizati ...
Recent evidence suggests that the heart possesses a greater regeneration capacity than previously thought. In the present study, we isolated undifferentiated precursors from the cardiac nonmyocyte cell population of neonatal hearts, expanded them in cultur ...
