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What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip

Publications associées (63)

The Intestinal Epithelium

The mammalian intestine is a prototype of a self-renewing organ. The rapid cellular turnover is supported by proliferating progenitors located in the intestinal crypt, which is also the stem cell location. Homeostasis of the intestinal epithelium has to be ...

EPFL2011

Role of Bcl9 and Bcl9l in Homeostasis, Regeneration and Tumorigenesis of the Gastrointestinal Epithelium

Norbert Wiedemann

Wnt signaling is essential for embryogenesis and adult tissue homeostasis and contributes to cancer development, especially in the colon. A new essential pathway component, legless, was identified in Drosophila melanogaster. Mice with Cre/loxP-mediated con ...

EPFL2011

Etude expérimentale de refuges à poissons aménagés dans les berges de rivières soumises aux éclusées hydroélectriques

Jean-Marc Ribi

Downstream of hydroelectric storage dams, the rivers suffer from rapid, frequent and intense flow variations linked to the power production constraints. Subjected to this hydropeaking phenomenon, the fish population suffers from a known decline. In the res ...

EPFL2011

Adverse Outcome Pathways during Early Fish Development: A Conceptual Framework for Identification of Chemical Screening and Prioritization Strategies

Kristin Schirmer

The fish early life-stage (FELS) test guideline (OECD 210 or OCSPP 850.1400) is the most frequently used bioassay for predicting chronic fish toxicity and supporting aquatic ecological risk assessments around the world. For each chemical, the FELS test req ...

Oxford University Press2011

Development of a novel biomaterial for drug delivery

Anu Kodiyan

Gold nanoparticles (GNPs) are promising tools as drug delivery devices. However, upon intravenous injection, they aggregate and are rapidly eliminated from the systemic circulation by macrophages in the reticuloendothelial system, resulting in relatively s ...

2011

Cooperative prey herding based on diffusion adaptation

Ali H. Sayed

Mobile adaptive networks consist of a collection of nodes with learning and motion abilities that interact with each other locally in order to solve distributed processing and distributed inference problems in real-time. In this paper, we develop adaptatio ...

IEEE2011

Flow exchange between a channel and a rectangular embayment equipped with a diverting structure

Anton Schleiss, Jean-Marc Ribi

In the framework of a research project focusing on mitigation measures for hydropeaking, a lateral embayment in riverbank is studied as a fish shelter. With the goal to find attractive configurations of shelter, systematic experiments with wild juvenile br ...

Ed. Dittrich, Koll, Aeberle & Geisenhainer (eds)2010

Fish behavior during hydropeaking in a channel equipped with a lateral shelter

Anton Schleiss, Jean-Marc Ribi

In the framework of a research project focusing on mitigation measures for hydropeaking, a lateral embayment at the channel bank is studied as a fish refuge. Systematic experiments with different refuge configurations were carried out. The basic configurat ...

2010

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas

Michel Aguet, Mauro Delorenzi, Pascale Anderle Pedone, Norbert Wiedemann, Sylvie André Baflast

Canonical Wnt signaling plays a critical role in stem cell maintenance in epithelial homeostasis and carcinogenesis. Here, we show that in the mouse this role is critically mediated by Bcl9/Bcl9l, the mammalian homologues of Legless, which in Drosophila is ...

American Association for Cancer Research2010

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

Johan Auwerx, Kristina Schoonjans

BACKGROUND & AIMS: The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear receptors are transcription factors funct ...

2010

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