Publication
High-fat diet consumption alters energy metabolism in the mouse hypothalamus
Publications associées (36)
Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations
Magnetic resonance spectroscopy is a powerful, non-invasive, quantitative imaging technique that allows for the measurement of brain metabolites that has demonstrated utility in diagnosing and characterizing a broad range of neurological diseases. Its impa ...
FRONTIERS MEDIA SA2023Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal
João Miguel das Neves Duarte, Adélaïde Alice Mohr
Diabetes impacts on brain metabolism, structure, and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. Howe ...
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Weber et al. provide evidence in support of a stress-diathesis model of functional neurological disorders. They identify trauma history in the form of emotional neglect as a psychological risk factor, and reduced hippocampus and amygdala volume as a predis ...
OXFORD UNIV PRESS2022Diamond-Based Nanoscale Quantum Relaxometry for Sensing Free Radical Production in Cells
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WILEY-V C H VERLAG GMBH2022Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity
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Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implic ...
CELL PRESS2021Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet
João Miguel das Neves Duarte, Ana Francisca Leal Silva Soares, Blanca Lizarbe Serra
Metabolic syndrome and diabetes impact brain function and metabolism. While it is well established that rodents exposed to diets rich in saturated fat develop brain dysfunction, contrasting results abound in the literature, likely as result of exposure to ...
2019Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses
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The two stress-responsive physiological systems, autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis exert complementary and interrelated actions in the organism. Individuals that suffer stress-related psychopathologies frequently ...
2019Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism
Lijing Xin, João Miguel das Neves Duarte
In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in ne ...
2019Thyrotropin-secreting pituitary adenomas: a systematic review and meta-analysis of postoperative outcomes and management
PurposeTSH-secreting pituitary adenomas are rare pituitary tumors. An efficient treatment is essential to limit the mortality and morbidity in untreated patients. The aim of this study is to summarize the evidence about the postoperative outcomes and manag ...
SPRINGER2019In Vivo Heteronuclear Magnetic Resonance Spectroscopy
Rolf Gruetter, Antoine Timothée Cherix, Blanca Lizarbe Serra
Magnetic Resonance Spectroscopy is a technique that has the capability of measuring metabolites in vivo and, in appropriate conditions, to infer its metabolic rates. The success of MRS depends a lot on its sensitivity, which limits the usage of X-nuclei MR ...
Springer2018