Publication

Impact of MCT1 Haploinsufficiency on the Mouse Retina

Publications associées (35)

Retinal and post-retinal contributions to the quantum efficiency of the human eye revealed by electrical neuroimaging

The retina is one of the best known quantum detectors with rods able to reliably respond to single photons. However, estimates on the number of photons eliciting conscious perception, based on signal detection theory, are systematically above these values ...

Frontiers Research Foundation2013

Whole-Exome Sequencing Identifies Mutations in GPR179 Leading to Autosomal-Recessive Complete Congenital Stationary Night Blindness

Congenital stationary night blindness (CSNB) is a heterogeneous retinal disorder characterized by visual impairment under low light conditions. This disorder is due to a signal transmission defect from rod photoreceptors to adjacent bipolar cells in the re ...

2012

Reflectance imaging of the human retina at 810 nm does not suffice to optimize the parameters of hydrodynamic rebalancing laser treatment

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Filippo Piffaretti

The hydrodynamic rebalancing laser (HRL) procedure is an ophthalmic therapy based on the administration of subthreshold infrared (810 nm) laser light to selected areas on the retina to treat various retina diseases. Heterogeneities of tissue response are o ...

Spie-Soc Photo-Optical Instrumentation Engineers2012

Angiogenesis inhibition by the maleimide-based small molecule GNX-686

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

We investigated the anti-angiogenic properties of GNX-686, a newly identified maleimide-based small molecule. In vitro studies on HUVEC showed that GNX-686 inhibited cell growth with an ED50 of 20-25 mu M, while human HeLa tumor cells and non-transformed e ...

Elsevier2012

Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

Pascal Escher

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated by genes such as nuclear hormone receptors. The nucle ...

Public Library of Science2011

Analysis of Factors Affecting the Performance of Retinal Prostheses Using Finite Element Modelling of Electric Field Distribution in the Retina

Sri Harsha Kasi Raj

This dissertation proposes a computational framework targeted at improving the design of currently employed retinal prostheses. The framework was used for analysing factors impacting the performance of prostheses in terms of electrical stimulation for reti ...

EPFL2011

Acute Hypoglycemia Induces Retinal Cell Death in Mouse

Martine Emery

Background: Glucose is the most important metabolic substrate of the retina and maintenance of normoglycemia is an essential challenge for diabetic patients. Glycemic excursions could lead to cardiovascular disease, nephropathy, neuropathy and retinopathy. ...

Public Library of Science2011

Direct localised measurement of electrical resistivity profile in rat and embryonic chick retinas using a microprobe

Philippe Renaud, Arnaud Bertsch, Harald Van Lintel, Robert Meissner, Sri Harsha Kasi Raj

We report an alternative technique to perform a direct and local measurement of electrical resistivities in a layered retinal tissue. Information on resistivity changes along the depth in a retina is important for modelling retinal stimulation by retinal p ...

University of Oslo2010

Frequency encoded assessment of retinal physiology - art. no. 684401

Theo Lasser, Rainer Leitgeb, Adrian Bachmann, Roland Michaely, Cédric Blatter

We demonstrate in-vivo functional imaging of the human retina with Fourier domain optical coherence tomography employing frequency encoding of an excitation pattern. The principle is based on projecting a modulated rectangular pattern across the foveal reg ...

Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa2008

Triggering of Bcl-2-related pathway is associated with apoptosis of photoreceptors in Rpe65(-/-) mouse model of Leber's Congenital Amaurosis

Mutations in RPE65 protein is characterized by the loss of photoreceptors, although the molecular pathways triggering retinal cell death remain largely unresolved. The role of the Bcl-2 family of proteins in retinal degeneration is still controversial. How ...

2008

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