A 1,3,2-Diazaphospholene-Catalyzed Reductive Claisen Rearrangement
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EPFL2020
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The potent nucleophilicity and remarkably low basicity of 1,3,2- diazaphospholenes (DAPs) is exploited in a catalytic, metal-free 1,4-reduction of free ,-unsaturated carboxylic acids. Notably, the reduction occurs without a prior deprotonation of the car ...