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Tourette syndrome is characterized by 'unvoluntary' tics, which are compulsive, yet often temporarily suppressible. The inferior frontal gyms is implicated in motor control, including inhibition of pre-potent actions through influences on downstream subcor ...
First human trials involving neuroprosthetic rehabilitation demonstrated recently that significant
functional benefits can be achieved with lumbosacral neuromodulation and reorganized
spared projections. However, complete spinal cord injuries (SCI) wholly ...
Spinal cord injury (SCI) impairs the flow of sensory and motor signals between the brain and the areas of the body located below the lesion level. Here, we describe a neurorehabilitation setup combining several approaches that were shown to have a positive ...
All human actions involve motor control. Even the simplest movement requires the coordinated recruitment of many muscles, orchestrated by neuronal circuits in the brain and the spinal cord. As a consequence, lesions affecting the central nervous system, su ...
Walking patterns of persons affected by cerebellar ataxia (CA) are characterized by wide stride-to-stride variability ascribable to: the background pathology-related sensory-motor noise; the motor redundancy, i.e., an excess of elemental degrees of freedom ...
The reduction of aversive emotions by a conspecific’s presence—called social buffering—is a universal phenomenon in the mammalian world and a powerful form of human social emotion regulation. Animal and human studies on neural pathways underlying social bu ...
Are the muscle synergies extracted from multiple electromyographic signals an expression of neural information processing, or rather a by-product of mechanical and task constraints? To address this question, we asked 41 right-handed adults to perform a var ...
Vassiliadis P, Derosiere G, Grandjean J, Duque J. Motor training strengthens corticospinal suppression during movement preparation. J Neurophysiol 124: 1656-1666, 2020. First published September 30, 2020; doi:10.1152/jn.00378.2020.-Training can improve mot ...
Biological motor control is versatile and efficient. Muscles are flexible and undergo continuous changes requiring distributed adaptive control mechanisms. How proprioception solves this problem in the brain is unknown. Here we pursue a task-driven modelin ...
Spinal cord injury (SCI) leads to permanent deficits in sensory and motor function due to the physical disruption of descending and ascending pathways. As a consequence, spinal circuits below the level of lesion remain in an intact, but inactive state. A n ...