Decoupling of brain function from structure reveals regional behavioral specialization in humans
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The BOLD contrast is widely used to study brain function. Under externally-applied stimuli, positive BOLD responses (PBR) are generally attributed to local increases in brain activity. Negative BOLD responses (NBR) are also frequently observed, but their u ...
The brain is the most mysterious and intricate biological structure known to man. It dominates the way we live, think, reason and behave. It is built of billions of neurons that communicate with each other through trillions of connections using electrical ...
The development of the human brain, from the fetal period until childhood, happens in a series of intertwined neurogenetical and histogenetical events that are influenced by environment. Neuronal proliferation and migration, cell aggregation, axonal ingrow ...
Confirmatory approaches to fMRI data analysis look for evidence for the presence of pre-defined regressors modeling contributions to the voxel time series, including the BOLD response following neuronal activation. As more complicated questions arise about ...
Brain fluctuations at rest are not random but are structured in spatial patterns of correlated activity across different brain areas. The question of how resting-state functional connectivity (FC) emerges from the brain's anatomical connections has motivat ...
Magnetic resonance imaging (MRI) has opened unprecedented avenues to observe the human brain non-invasively. In particular, for about two decades, functional MRI (fMRI) has enabled to monitor brain function using the blood-oxygen-level-dependent (BOLD) con ...
Genetic approaches to control DNA expression in different brain areas have provided an excellent system to characterize gene function in health and disease of animal models. With respect to others, in utero electroporation of exogenous DNA into progenitor ...
Neurons in the brain form highly complex networks through synaptic connections. Traditionally, functional connectivity between neurons has been explored using methods such as correlations, which do not contain any notion of directionality. Recently, an inf ...
Functional connectivity analysis of fMRI data can reveal synchronised activity between anatomically distinct brain regions. Here, we extract the characteristic connectivity signatures of different brain states to perform classification, allowing us to deco ...
Real-time monitoring of neurotransmitters is of utmost importance for understanding the functioning of the brain. Especially L-glutamate and choline play a major role in chemical signalling and are highly involved in cognitive functions such as learning, m ...
