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Identifying gene function and module connections by the integration of multispecies expression compendia

Publications associées (33)

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Ellipse-Preserving Hermite Interpolation and Subdivision

Michaël Unser

We introduce a family of piecewise-exponential functions that have the Hermite interpolation property. Our design is motivated by the search for an effective scheme for the joint interpolation of points and associated tangents on a curve with the ability t ...

Elsevier2015

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses

Amalio Telenti, Danielle Thompson, Daniel Sauter, Jérémie Perreaud

Background: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins. To identify potential novel restriction ...

Biomed Central Ltd2015

Identification of HMX1 target genes: A predictive promoter model approach

Purpose: A homozygous mutation in the H6 family homeobox 1 (HMX1) gene is responsible for a new oculoauricular defect leading to eye and auricular developmental abnormalities as well as early retinal degeneration (MIM 612109). However, the HMX1 pathway rem ...

Molecular Vision2013

The impact of host genetic variation on determining the differential outcomes after HIV infection has been studied by two approaches: targeting of candidate genes and genome-wide association studies (GWASs). The overlap in genetic variants that has been id ...

Lippincott, Williams & Wilkins2013

The Hourglass and the Early Conservation Models-Co-Existing Patterns of Developmental Constraints in Vertebrates

Pawel Lichocki

Developmental constraints have been postulated to limit the space of feasible phenotypes and thus shape animal evolution. These constraints have been suggested to be the strongest during either early or mid-embryogenesis, which corresponds to the early con ...

Public Library Science2013

Adenylyl cyclase type 5 knockout mice (AC5 KO) live longer and are stress resistant, similar to calorie restriction (CR). AC5 KO mice eat more, but actually weigh less and accumulate less fat compared to WT mice. CR applied to AC5 KO result in rapid decrea ...

Wiley-Blackwell2012

Origins and consequences of transcriptional discontinuity

Felix Naef, David Michael Suter

In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single ...

2011

Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals

Jacques Fellay, Patrick Descombes, Amalio Telenti

There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, the contribution of variable gene e ...

2010

Functions With Orthogonal Hessian

Bernard Dacorogna

A Dirichlet problem for orthogonal Hessians in two dimensions is explicitly solved, by characterizing all piecewise C-2 functions u Omega subset of R-2 -> R with orthogonal Hessian in terms of a property named "second order angle condition" as in (1 1) ...

2010

Gene expression profiling in cells with enhanced gamma-secretase activity

Alexandra Marie-Isabelle Karoline Brigitte Magold, Patrick Fraering

BACKGROUND: Processing by gamma-secretase of many type-I membrane protein substrates triggers signaling cascades by releasing intracellular domains (ICDs) that, following nuclear translocation, modulate the transcription of different genes regulating a div ...

Public Library of Science2009