Publication
Acting as an extracellular matrix protein receptor, alpha(v)beta(3) integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific alpha(v)beta(3)-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-R-n) are demonstrated as off-on theranostic agents, where R-n are specific peptides. Among them, Gd-PEG-R-3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R-3 is proven by its high alpha(v)beta(3) integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R-3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer.
Grégoire Courtine, Jocelyne Bloch, Jordan Squair
Yves Perriard, Yoan René Cyrille Civet, Stefania Maria Aliki Konstantinidi, Amine Benouhiba, Quentin Philippe Mario De Menech, Sloan Zammouri