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Strategies to Functionalize the Anionic Biopolymer Na-Alginate Without Restricting its Polyelectrolyte Properties

Publications associées (22)

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Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation

Sandrine Gerber, François Rémi Pierre Noverraz, Jutta Christine Wandrey, Solène Marcelle Françoise Marie Passemard, Luca Szabó

The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...

Amer Chemical Soc2017

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

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Valorization of CO2, an abundant C(1) synthon, into platform chemicals is of growing interest. In this context, a key reaction is the cycloaddition of CO2 to epoxides to form carbonates (CCE). A series of organocatalysts for this reaction, based on imidazo ...

Wiley-Blackwell2016

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Two novel types of hydrogel microspheres (MS) are presented. First, one-component microspheres (1-comMS) were produced from sodium alginate (Na-alg) equipped with thiolfunctionalized hydroxyl groups. The functionalization pathway included the conversion of ...

American Chemical Society2015

Synthesis and properties of polymeric analogs of ionic liquids

Jutta Christine Wandrey

A number of methacrylate ionic monomers with different structures and mobilities of ionic centers were synthesized. The free-radical polymerization of these monomers in solution affords high-molecular-mass (M (sD) = 0.5 to 2.5 x 10(6)) thermally stable (T ...

Maik Nauka/Interperiodica/Springer2013

A new non-toxic chemically cross-linked ELP hydrogel for in situ protein delivery

Karine Ciapala

Proteins play an essential role in all biological processes and have been attracting more and more attention as drug candidates due to their high specificity and activity. However, their use as therapeutics has been seriously held back given that their abi ...

2009

Gene delivery from responsive hyaluronic acid hydrogels for directed angiogenesis

Arnaud Felber

Tissue Engineering points to maintain, restore or to improve and create new tissues. This purpose typically involves the selection of a natural or synthetic biomaterial as a scaffold to create the biological substitutes. Furthermore, angiogenesis, the grow ...

2008

Microfluidic patterning of alginate hydrogels

Philippe Renaud

In this article the authors present techniques which allow the microfluidic design of alginate microgels with layer composition on a chip. The hydrogel is created by combining two laminar flows of the gel precursor solutions-a calcium solution and an algin ...

American Vacuum Society2007

Alginate-based microcapsules for mammalian cell culture and other biotechnological applications

Véronique Breguet

Since life began, nature has been using the envelopment of systems for their protection or for providing a particular reaction space, the enveloping wall displaying additional specific membrane functions. The abundance of examples is quite overwhelming and ...

EPFL2007

Gentle cell trapping and release on a microfluidic chip by in situ alginate hydrogel formation

Philippe Renaud, Thomas Michael Braschler, Lynda Metref

Microfluidic devices are increasingly used to perform biological experiments on a single-cell basis. However, long-term stability of cell positions is still an issue. A novel biocompatible method for cell entrapment and release on a microchip is presented. ...

2005