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Synthetic Studies toward Amanita Phalloides Toxins

Publications associées (110)

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Investigations of the Chemistry of 1-Alkynyltriazenes

Florian Gérald Abela

The chemistry of aromatic triazenes is well known, and has been explored for more than a century. These compounds have emerged as very useful intermediates, because of their unique reactivity. This functionality can notably be used to access many other fun ...

EPFL2018

Metal-Organic-Framework-Derived Co3S4 Hollow Nanoboxes for the Selective Reduction of Nitroarenes

Wendy Lee Queen, Emad Oveisi, Daniel Teav Sun, Shuliang Yang, Li Peng, Safak Bulut

MOF-derived Co3S4/CN hollow nanoboxes (CN=nitrogen-doped carbon) was used to catalyze the chemoselective reduction of nitroarenes to anilines under mild reaction conditions with H-2 as the reducing agent. The catalyst provides high conversion efficiencies ...

2018

Drugs Based on de novo-developed Peptides are Coming of Age

Christian Heinis

Naturally evolved peptides, such as the hormone oxytocin or the anti-bacterial vancomycin, have seen decades of success as powerful therapeutics due to many of the favorable properties of peptides. Not every desired target has a naturally occurring bioacti ...

SWISS CHEMICAL SOC2018

Guessing the Fingerings

Samuel Pierre Rey

Some strings instruments, such as guitar or violin, can play the same note using different fingerings. To find out which string has been used, we developed an algorithm that compute the inharmonicity of a given audio sample, and then use it to identify the ...

2018

Cyclic peptide therapeutics: past, present and future

Christian Heinis, Alessandro Zorzi

Cyclic peptides combine several favorable properties such as good binding affinity, target selectivity and low toxicity that make them an attractive modality for the development of therapeutics. Over 40 cyclic peptide drugs are currently in clinical use an ...

2017

A Roadmap for the Development of Precision Medicine

Marie-Valentine Renée Agnès Florin, Gérard Escher

The purpose of the roadmap proposed by IRGC is to recommend a structured process that organisations can follow in their transition towards the development of precision medicine. The process is adaptable, and each organisation should further develop it to a ...

International Risk Governance Center (IRGC)2017

Scientific diasporas, transnationalism and home-country development: evidence from a study of skilled Moldovans abroad

Gabriela Tejada Guerrero

This chapter discusses the Moldovan scientific diaspora made up of students, researchers and those engaged in Professional activities abroad, and their propensity to either return or engage in home-country development initiatives. Moldova has suffered a si ...

Routledge2017

Methyltransferase-Directed Labeling of Biomolecules and its Applications

Jochem Deen

Methyltransferases (MTases) form a large family of enzymes that methylate a diverse set of targets, ranging from the three major biopolymers to small molecules. Most of these MTases use the cofactor S-adenosyl-l-Methionine (AdoMet) as a methyl source. In r ...

Wiley-V C H Verlag Gmbh2017

The microfluidic nebulator: production of submicrometer sized airborne drops

Esther Amstad

Many powders employed in the food and pharmaceutical industries are produced through spray drying because it is a cost efficient process that offers control over the particle size. However, most commercially available spray-driers cannot produce drops with ...

Royal Soc Chemistry2017

SLA: to Sign or Not to Sign

Gil Regev, Alain Wegmann, Gorica Tapandjieva Sekulovska

We present our experience of a three-week fieldwork in the form of a contextual inquiry with a service manager at the EPFL IT department. During these three weeks, we encounter a refusal of a user committee to sign a service-level agreement (SLA). We descr ...

CEUR Workshop Proceedings2016