Publication
In vivo detection of gamma-glutamyl-transferase up-regulation in glioma using hyperpolarized gamma-glutamyl-[1-C-13]glycine
Publications associées (34)
The role of LRRK2 in lung adenocarcinoma
Lung cancer is the leading cause of cancer-related deaths worldwide and the most commonlung cancer subtype is lung adenocarcinoma (LUAD). Frequently mutated genes involveactivating mutations in KRAS and loss of function mutations in TP53. LUADs primarily a ...
EPFL2024A fatty-acid based probe for near-infrared fluorescence guided surgery of glioblastoma
Elena Goun, Pavlo Khodakivskyi
High-grade gliomas (HGG) are the most common and most aggressive primary tumors of the brain. Despite recent advances in neuro-oncology survival of these tumors remains around 12-15 months. The first-line of treatment is surgical resection. However, due to ...
Spie-Int Soc Optical Engineering2024Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit
Glioblastoma (GBM) is the most frequent and highly malignant form of brain cancer. New therapeutic regimens are urgently needed as GBM patients present with a minimal response to currently-approved therapies. The goal of this project is to identify new the ...
EPFL2023The role of eosinophils in breast cancer
Eosinophils are granulocytes and belong to the innate arm of immunity. Eosinophils can be in different basal or activation states and depending on which type of activation is applied, they exert different effector functions. These multi-functional cells ha ...
EPFL2022Trigeminal Neuralgia Secondary to Meningiomas and Vestibular Schwannoma Is Improved after Stereotactic Radiosurgery: A Systematic Review and Meta-Analysis
Introduction: Trigeminal neuralgia (TN) secondary to tumors is encountered in up to 6% of patients with facial pain syndromes and is considered to be associated with tumors affecting the trigeminal nerve pathways. The most frequent are meningiomas and vest ...
KARGER2021An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells
Fabien Louis Claude Robert Jammes
Cancer represents one of the major public health challenges worldwide, representing more than 25% of all deaths in the European Union in 2014. It affects a large and growing part of the general population, with the National Cancer Institute (NCI) estimatin ...
EPFL2021Standardized intraoperative 5-ALA photodynamic therapy for newly diagnosed glioblastoma patients: a preliminary analysis of the INDYGO clinical trial
Purpose Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The unfavorable prognosis despite maximal therapy relates to high propensity for recurrence. Thus, overall survival (OS) is quite limited and local failure remains the fundame ...
2021Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme
Malignant gliomas represent 80% of tumors developing in the central nervous system, with 50% being glioblastomas (GBM), the most aggressive form of the disease. The benefit from current therapies is very limited, the overall 5-year survival rate of patient ...
EPFL2018Chemo-manipulation of tumor blood vessels by a metal-based anticancer complex enhances antitumor therapy
Paul Joseph Dyson, Hubert van den Bergh, Tina Riedel
Human pleural mesothelioma is an incurable and chemoresistant cancer. Using a nude mouse xenograft model of human pleural mesothelioma, we show that RAPTA-T, a compound undergoing preclinical evaluation, enhances tumor vascular function by decreasing blood ...
2018Directional Entropy Based Model For Diffusivity-Driven Tumor Growth
In this work, we present and investigate a multiscale model to simulate 3D growth of glioblastomas (GBMs) that incorporates features of the tumor microenvironment and derives macroscopic growth laws from microscopic tissue structure information. We propose ...
Amer Inst Mathematical Sciences-Aims2016