Publication

A fatty-acid based probe for near-infrared fluorescence guided surgery of glioblastoma

Elena Goun, Pavlo Khodakivskyi
2024
Article de conférence
Résumé

High-grade gliomas (HGG) are the most common and most aggressive primary tumors of the brain. Despite recent advances in neuro-oncology survival of these tumors remains around 12-15 months. The first-line of treatment is surgical resection. However, due to its infiltrative nature maximal safe resection leaves residual invasive cancer cells that lead to disease recurrence. Most recurrences are in or near the resection cavity. Advances in optical imaging techniques might aid better delineation of the invasive margin intraoperatively. However as of yet most of these technologies have failed to do so consistently. Recently, alterations in fatty acid metabolism have been linked to the initiation, progression, and recurrence of gliomas. These alterations might provide a novel target for better differentiation of glioma cells and healthy brain tissue. To exploit this, we introduce and test a novel, near-infrared, fluorescent dye, fatty-acid indocyanine green (FA-ICG) in vitro and in vivo. We hypothesize that the combination of targeting mechanism, and the near-infrared properties make FA-ICG a promising candidate for further clinical translation in fluorescence-guided surgery.

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Concepts associés (33)
Tumeur du cerveau
vignette|Biopsie du cerveau vignette|Scanner du cerveau d'une fillette de 6 ans atteinte d'un médulloblastome (tumeur cérébrale la plus fréquente chez les enfants de moins de 2 ans). Les tumeurs cérébrales désignent l'ensemble des tumeurs, bénignes ou malignes, se développant dans le parenchyme cérébral. Elles surviennent par le développement anormal et désorganisé de divisions cellulaires, à partir soit d'une cellule du cerveau lui-même, soit d'une cellule métastatique exportée d'un cancer situé dans une autre partie du corps.
Gliome
Les gliomes ou tumeurs gliales sont l'ensemble des tumeurs cérébrales, bénignes ou malignes, issues du tissu de soutien neuronal ou glie. Ce sont des tumeurs rares, dont le pronostic, extrêmement variable, est principalement lié à plusieurs facteurs parmi lesquels la localisation, la taille, le degré d'extension ou certains facteurs immunitaires. Elles justifient toujours une prise en charge dans un service spécialisé afin d'adapter au mieux le projet de soins à la situation du patient.
Fatty acid metabolism
Fatty acid metabolism consists of various metabolic processes involving or closely related to fatty acids, a family of molecules classified within the lipid macronutrient category. These processes can mainly be divided into (1) catabolic processes that generate energy and (2) anabolic processes where they serve as building blocks for other compounds. In catabolism, fatty acids are metabolized to produce energy, mainly in the form of adenosine triphosphate (ATP).
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Publications associées (33)

Mechanisms and functions of protein S-acylation

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Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...
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Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

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Glioblastoma (GBM) is the most frequent and highly malignant form of brain cancer. New therapeutic regimens are urgently needed as GBM patients present with a minimal response to currently-approved therapies. The goal of this project is to identify new the ...
EPFL2023

Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Mor-Miri Mishkovsky, Jocelyne Bloch, Arnaud Comment

Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard ...
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