Publication
PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage
Publications associées (37)
Functional analysis of the telomeric long non-coding RNA TERRA
Telomeres are nucleoprotein structures present in the end of linear chromosomes. In humans, a core complex of 6 proteins cap and protect the chromosome ends from being recognized as double-strand breaks and eliciting unwanted DNA damage and repair response ...
EPFL2019Expression and differential regulation of human TERRA at several chromosome ends
Joachim Lingner, Marianna Feretzaki, Patricia Renck Nunes
The telomeric long noncoding RNA TERRA has been implicated in regulating telomere maintenance by telomerase and homologous recombination, and in influencing telomeric protein composition during the cell cycle and the telomeric DNA damage response. TERRA tr ...
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2019Telomeric states in cancer development
Telomere dysfunction can unleash genome instability or permanently arrest cell proliferation, and thereby contribute to the processes of cancer and aging. Proper telomere function relies on many proteins that form part of its structure. Some telomeric prot ...
EPFL2018The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors
Telomeres are dynamic nucleo-protein structures capping the ends of all eukaryotic chromosomes. Together with telomerase, they counteract replication-dependent telomere attrition. Additionally, they disguise the linear ends of the chromosome from the DNA d ...
EPFL2018The telomeric DNA damage response occurs in the absence of chromatin decompaction
Joachim Lingner, Suliana Manley, Kyle Michael Douglass, Verena Pfeiffer, Aleksandra Vancevska
Telomeres are specialized nucleoprotein structures that protect chromosome ends from DNA damage response (DDR) and DNA rearrangements. The telomeric shelterin protein TRF2 suppresses the DDR, and this function has been attributed to its abilities to trigge ...
Cold Spring Harbor Laboratory2017TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection
The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps similar to 90 bp of DNA through several lysine and arginine residues localiz ...
Cell Press2016Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase
Joachim Lingner, Viesturs Simanis, Sophie Redon, Wareed Ahmed, Eric Aeby
Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and show th ...
Elsevier2016No DDRama at chromosome ends: TRF2 takes centre stage
Antonio Porro, Liuh-Yow Chen, Sascha Feuerhahn
Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inapp ...
Elsevier Science London2015Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold
Homing endonucleases are useful tools for genome modification because of their capability to recognize and cleave specifically large DNA targets. These endonucleases generate a DNA double strand break that can be repaired by the DNA damage response machine ...
American Society for Biochemistry and Molecular Biology2015NAR Breakthrough Article Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination
Matteo Dal Peraro, Alexandra Styliani Kalantzi
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism. Here, the crystal structure of Hop2-Mnd1 reveals that it form ...
Oxford University Press2015