Publication
Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design
Publications associées (38)
Quasistatic and dynamic force microscopy of single antigen-antibody complexes and fibrin-fibrinogen systems
The molecular processes based on the specific receptor-ligand interactions (e.g. immune response to a foreign antigen, communication between nerve cells, etc.) are essential for a good and stable performance of living organisms. The aim of the present work ...
EPFL2004Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10
Culture filtrate protein 10 (CFP-10) from Mycobacterium tuberculosis is a well-characterized immunodominant 10-kDa protein antigen known to elicit a very potent early gamma interferon response in T cells from M. tuberculosis-infected mice and humans. The s ...
2004Immunoaffinity screening with capillary electrochromatography
Horst Vogel, Michael Mayer, Markus Ehrat
Highly efficient capillary electrochromatog. sepns. of cardiac glycosides and other steroids are presented. Employing butyl-derivatized silica particles as stationary phase resulted in a nearly three times faster electroosmotic flow (EOF) compared to capil ...
2002Generation of monospecific peptide antibodies to the DNA binding domain of p53
The DNA binding domain (DBD) is the most mutated region of p53 in tumors and has proven to be relatively resistant to the generation of specific antibodies. Template assembled synthetic peptide (TASP) synthesis of a peptide derived from the DBD creates a h ...
2000CD80 costimulation is essential for the induction of airway eosinophilia
CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We ...
1997Surface engineering: optimization of antigen presentation in self-assembled monolayers
The formation of self-assembled monolayers (SAMs) on gold surfaces contg. an antigenic peptide (NANP)6 and HS(CH2)11OH, and the specific binding of a monoclonal antibody to these layers were investigated by surface plasmon resonance (SPR). Peptides were sy ...
1996Partial characterization of natural and recombinant human soluble CD23
The purification to homogeneity of an active soluble 25 kDa fragment of CD23, produced in insect cells using the baculovirus expression system, is described. Peptide mapping and analysis by Edman degradation and mass spectrometry permitted partial characte ...
1992Designing CD4 immunoadhesins for AIDS therapy
A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to blo ...
1989