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Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

Publications associées (40)

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Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Xiaoxu Li

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

EPFL2023

Impact of population size on early adaptation in rugged fitness landscapes

Anne-Florence Raphaëlle Bitbol, Richard Marie Servajean

Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...

ROYAL SOC2023

The Montecristo wild goat is an endangered feral population that has been on the homonymous island in the Tuscan Archipelago since ancient times. The origins of Montecristo goats are still debated, with authors dating their introduction either back to Neol ...

MDPI2022

Simple automation of SEM-EDS spectral maps analysis with Python and the edxia framework

Karen Scrivener, Fabien Jacques Michel Georget, William Wilson

In a recent article, we described the edxia framework, a user-friendly framework to analyse the microstructure of cementitious materials using SEM-EDS hypermaps. The manual approach presented was shown to be efficient to answer the relevant scientific ques ...

WILEY2022

The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that i ...

National Academy of Sciences2022

Combating Online Scientific Misinformation

Panagiotis Smeros

The drastic shift towards digital communication in our mediasphere has caused a profound change in the production and consumption of information, which in turn has substantial implications on the social and political landscape. Misinformation, as a side ef ...

EPFL2022

Science on the Summit: Exploring Scientific Tourism Through the Lens of Eighteenth Century Mountain Ascents

Jérôme Baudry, Ion-Gabriel Mihailescu, Simon François Dumas Primbault

This contribution argues that a particular scientific context made summits a place of interest for eighteenth-century travelers. This development is connected to two particular scientific practices. First, the challenges raised by making the barometer into ...

2022

The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine. The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...

EPFL2021

The population genetics of crypsis in vertebrates: recent insights from mice, hares, and lizards

Jeffrey David Jensen, Susanne Petra Pfeifer, Stefan Jean Laurent

By combining well-established population genetic theory with high-throughput sequencing data from natural populations, major strides have recently been made in understanding how, why, and when vertebrate populations evolve crypsis. Here, we focus on backgr ...

NATURE PUBLISHING GROUP2020

Limits on amplifiers of natural selection under death-Birth updating

Andreas Pavlogiannis

The fixation probability of a single mutant invading a population of residents is among the most widely-studied quantities in evolutionary dynamics. Amplifiers of natural selection are population structures that increase the fixation probability of advanta ...

PUBLIC LIBRARY SCIENCE2020