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Surface-enhanced Raman scattering (SERS) spectroscopy is one of the most prospective methods combining state-of-the-art nanomaterials and optical techniques for highly sensitive express-analysis and detection of organic and bioorganic objects in liquids and gases. Special programs have been recently started all over the world to bring the SERS-spectroscopy closer to wide implementation in medical diagnostics, forensics, security, monitoring sanitary conditions, etc. Despite outstanding features of SERS-spectroscopy, its effective practical use has been particularly slowed down by moderate reproducibility, non-versatility, and restrictions imposed by commercially available SERS-active substrates to measurement and storage regimes. The present review reports SERS-active substrates constituted by noble metals & rsquo; nanoparticles (NPs) and porous silicon (PS), which potentially can be a tool to overcome the above-mentioned limitations. The PS template acts as a highly ordered host nanomaterial for the formation of a variety of metallic nanostructures, which morphological and optical properties can be easily tuned for the best performance to meet the customer requirements via managing PS synthesis regimes. An indubitable advantage of PS is the compatibility of its fabrication process with basic microelectronics operations and micro-electromechanical systems (MEMS) that make it possible to integrate SERS-active areas in a silicon chip. In contrast to the previously published reviews in the field, this one covers the most recent results on formation, characterization, and application of PS-based substrates demonstrating prominent SERS-activity that have been achieved for the last decade including modifications with graphene or Bragg structures, detection of molecules at amount down to attomolar concentration, bacteria recognition, etc.