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Specific Protein-Membrane Interactions Promote Packaging of Metallo-beta-Lactamases into Outer Membrane Vesicles

Publications associées (46)

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Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress

Henning Paul-Julius Stahlberg

Several bacterial species produce membrane vesicles (MVs) in response to antibiotic stress. However, the biogenesis and role of MVs in bacterial antibiotic resistance mechanisms have remained unclear. Here, we studied the effect of the fluoroquinolone cipr ...

Wiley-Blackwell2017

Chemical communication is the basis of host-microbe interaction. Insights into this communication will provide a deeper understanding of the mechanisms that govern these complex associations, in beneficial as well as pathogenic contexts. In this dissertati ...

EPFL2017

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Alpha-synuclein is a presynaptic protein of poorly understood function that is linked to both genetic and sporadic forms of Parkinson's disease. We have proposed that alpha-synuclein may function specifically at synaptic vesicles docked at the plasma membr ...

Amer Chemical Soc2016

Integrated angular tracking and plasmonic membrane surfaces for a point of a care refractive index sensor

Hatice Altug, Harry Heinzelmann, Cenk Ibrahim Özdemir, Marie-Claude Bay

We present an optical system which integrates a plasmonic sensing surface and an angular tracking system to enable a compact refractive index measurement. A refractive index change at the surface of the sensing membrane causes a change in the angle at whic ...

Spie-Int Soc Optical Engineering2016

In situ synthesis and simulation of polydisperse amphiphilic membranes

Lida Kanari, Julian Charles Shillcock, Liesbeth Maria L Vanherpe, Guy Antoine Atenekeng Kahou, Juan Pablo Palacios

The field of coarse-grained simulations of biopolymers and membranes has grown rapidly in recent years. Industrial groups manufacture and use polymers in fields as diverse as chemicals processing and personal care products, while academic researchers are i ...

Springer India2015

Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states

Petr Leiman, Peng Ge

R-type pyocins are representatives of contractile ejection systems, a class of biological nanomachines that includes, among others, the bacterial type VI secretion system (T6SS) and contractile bacteriophage tails. We report atomic models of the Pseudomona ...

Nature Publishing Group2015

On-chip light sheet illumination enables diagnostic size and concentration measurements of membrane vesicles in biofluids

Philippe Renaud, Sébastien Jiguet, Hendrik Georges Deschout, Pietro Maoddi

Cell-derived membrane vesicles that are released in biofluids, like blood or saliva, are emerging as potential non-invasive biomarkers for diseases, such as cancer. Techniques capable of measuring the size and concentration of membrane vesicles directly in ...

Royal Soc Chemistry2014

Membrane properties revealed by spatiotemporal response to a local inhomogeneity

Anne-Florence Raphaëlle Bitbol

We study theoretically the spatiotemporal response of a lipid membrane submitted to a local chemical change of its environment, taking into account the time-dependent profile of the reagent concentration due to diffusion in the solution above the membrane. ...

Elsevier BV2013

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In the latest years the importance of high resolution analysis of the microbial cell surface has been increasingly recognized. Indeed, in order to better understand bacterial physiology and achieve rapid diagnostic and treatment techniques, a thorough inve ...

Elsevier2013

The present invention is directed towards magnetically responsive vesicular compositions comprising (a) a vesicular structure having a membrane enclosing a cavity and (b) at least one stabilized magnetic nanoparticle embedded in said membrane, and in parti ...

2013